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Pten Regulates Neuronal Arborization and Social Interaction in Mice
The data suggest that abnormal activation of the PI3K/AKT pathway in specific neuronal populations can underlie macrocephaly and behavioral abnormalities reminiscent of certain features of human ASD. Expand
Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System
Baohui Chen,1 Luke A. Gilbert,2,7 Beth A. Cimini,3,4 Joerg Schnitzbauer,1 Wei Zhang,1 Gene-Wei Li,2,7 Jason Park,2,5 Elizabeth H. Blackburn,3 Jonathan S. Weissman,2,6,7,8 Lei S. Qi,2,5,8,* and BoExpand
HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein.
It is shown that the herpes simplex virus type 1 (HSV-1)-encoded neurovirulence protein ICP34.5 binds to the mammalian autophagy protein Beclin 1 and inhibits its Autophagy function, which is essential for viral Neurovirulence. Expand
Visualization of membrane protein domains by cryo-electron microscopy of dengue virus
The structure of mature dengue virus particles was determined to a resolution of 9.5 Å by cryo-EM and image reconstruction techniques, establishing the secondary structural disposition of the 180 envelope (E) and 180 membrane (M) proteins in the lipid envelope. Expand
Pharmacological Inhibition of mTORC1 Suppresses Anatomical, Cellular, and Behavioral Abnormalities in Neural-Specific Pten Knock-Out Mice
Rapamycin, a specific inhibitor of mammalian target of rapamycin complex 1 (m TORC1), can prevent and reverse neuronal hypertrophy, resulting in the amelioration of a subset of PTEN-associated abnormal behaviors, providing evidence that the mTORC1 pathway downstream of PT EN is critical for this complex phenotype. Expand
Structures of immature flavivirus particles
Structures of prM‐containing dengue and yellow fever virus particles were determined to 16 and 25 Å resolution by cryoelectron microscopy and image reconstruction techniques, consistent with the predicted membrane‐spanning domains of the unprocessed polyprotein. Expand
Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status
Evidence is provided that miR-21 may serve as a novel therapeutic target for malignant gliomas independent of PTEN status and the GBM suppressor effect of antisense-miR- 21 is most likely independent ofPTEN regulation. Expand
Extracellular mutant SOD1 induces microglial‐mediated motoneuron injury
The data suggest that extracellular mSOD1G93A is not directly toxic to motoneurons but requires microglial activation for toxicity, utilizing CD14 and TLR pathways. Expand
Tolerization of dendritic cells by HLA‐G
Support is provided that HLA‐G is an important tolerogenic molecule on DC for the acceptance of a semiallogeneic fetus and transplanted tissue/organ and significantly prolonged allograft survival. Expand
Association of BRCA1 and BRCA2 mutations with survival, chemotherapy sensitivity, and gene mutator phenotype in patients with ovarian cancer.
Among women with high-grade serous ovarian cancer, BRCA2 mutation, but not BRC a1 deficiency, was associated with improved survival, improved chemotherapy response, and genome instability compared with BRCa wild-type. Expand