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A pneumonia outbreak associated with a new coronavirus of probable bat origin
Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats 1 – 4… Expand
Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor
The 2002–3 pandemic caused by severe acute respiratory syndrome coronavirus (SARS-CoV) was one of the most significant public health events in recent history. An ongoing outbreak of Middle East… Expand
Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes
ABSTRACT In December 2019, a novel coronavirus (2019-nCoV) caused an outbreak in Wuhan, China, and soon spread to other parts of the world. It was believed that 2019-nCoV was transmitted through… Expand
Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus
A large number of SARS-related coronaviruses (SARSr-CoV) have been detected in horseshoe bats since 2005 in different areas of China. However, these bat SARSr-CoVs show sequence differences from SARS… Expand
CD4(+)CD25(+)FoxP3(+) regulatory T cells suppress Mycobacterium tuberculosis immunity in patients with active disease.
CD4(+)CD25(+) regulatory T cells (Treg) play a central role in the prevention of autoimmunity and in the control of immune responses by down-regulating the function of effector CD4(+) or CD8(+) T… Expand
Distribution and fate of perfluoroalkyl substances in municipal wastewater treatment plants in economically developed areas of China.
Wastewater treatment plants (WWTPs) are a significant source for poly-/perfluoroalkyl substances (PFASs) entering the environment. The presence of PFASs in twenty-eight municipal WWTPs from eleven… Expand
Ursolic acid and its derivative inhibit protein tyrosine phosphatase 1B, enhancing insulin receptor phosphorylation and stimulating glucose uptake.
Protein tyrosine phosphatase 1B (PTP1B) is a key element in the negative regulation of the insulin signaling pathway and may play an important role in diabetes and obesity. We identified ursolic… Expand
A toolbox for light control of Drosophila behaviors through Channelrhodopsin 2‐mediated photoactivation of targeted neurons
- W. Zhang, Wooping Ge, Zuoren Wang
- Computer Science, Medicine
- The European journal of neuroscience
- 1 November 2007
In order to study the function of specific neural circuits, we generated UAS‐Channelrhodopsin2 (ChR2) transgenic Drosophila and established a ChR2‐based system that enables specific activation of… Expand
Molecular Basis of the Receptor Binding Specificity Switch of the Hemagglutinins from both the 1918 and 2009 Pandemic Influenza A Viruses by a D225G Substitution
ABSTRACT Influenza A virus uses sialic acids as cell entry receptors, and there are two main receptor forms, α2,6 linkage or α2,3 linkage to galactose, that determine virus host ranges (mammalian or… Expand
Characterization of a filovirus (Měnglà virus) from Rousettus bats in China
Filoviruses, especially Ebola virus (EBOV) and Marburg virus (MARV), are notoriously pathogenic and capable of causing severe haemorrhagic fever diseases in humans with high lethality1,2. The risk of… Expand