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LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation.
It is demonstrated that human LAT is palmitoylated and that palMIToylated LAT predominantly localizes into glycolipid-enriched microdomains (GEMs). Expand
Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling.
- W. Zhang, R. Trible, M. Zhu, S. K. Liu, C. McGlade, L. Samelson
- Biology, Medicine
- The Journal of biological chemistry
- 28 July 2000
The results strongly suggest that PLC-gamma activation regulates Ras activation in these cells, and show that three distal tyrosines, Tyr(171), Tyr(191), and Tyr(226), are responsible for Grb2-binding; Tyr( 171, and Tyr (191), but not Tyr( 226), are necessary for Gads binding. Expand
Molecular basis of T cell inactivation by CTLA-4.
CTLA-4 inhibits TCR signal transduction by binding to TCRzeta and inhibiting tyrosine phosphorylation after T cell activation, and these findings have broad implications for the negative regulation of T cell function and T cell tolerance. Expand
Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line.
- W. Zhang, B. Irvin, R. Trible, R. Abraham, L. Samelson
- Medicine, Biology
- International immunology
- 1 June 1999
It is demonstrated that LAT is required for TCR-mediated Ca2+ mobilization and optimal tyrosine phosphorylation of phospholipase C-gamma1, Vav and SLP-76, and the use of a LAT-deficient cell line for the analysis of LAT structure and function is demonstrated. Expand
Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT.
It is shown that TCR engagement triggers the formation and expansion of contacts bounded by continuously remodeled actin-rich rings, and the maintenance of the resulting contact requires sustained calcium influxes, an intact microtubule cytoskeleton, and functional LAT. Expand
Essential role of LAT in T cell development.
To probe the role of LAT in T cell development, the LAT gene was disrupted by targeting and normal B cell populations but the absence of any mature peripheral T cells were revealed. Expand
CXCR-4 (Fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types, including microglia and neurons.
- E. Lavi, J. Strizki, +6 authors F. González-Scarano
- Biology, Medicine
- The American journal of pathology
- 1 October 1997
The study of the expression of CXCR-4 in the brain may provide further insight into the interactions between brain cells, pathogens, and the immune system, and help understand the pathogenesis of HIV dementia. Expand
LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway.
Reexpression of LAT in J.CaM2 restored all aspects of TCR signaling, demonstrating a necessary and exclusive role for LAT in T cell activation. Expand
Crystal structure of the major histocompatibility complex class I H-2Kb molecule containing a single viral peptide: implications for peptide binding and T-cell receptor recognition.
- W. Zhang, A. C. Young, M. Imarai, S. Nathenson, J. Sacchettini
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 September 1992
The basis for binding of specific peptide sequences to the MHC class I molecule is the steric restriction imposed on the peptide side chains by the architecture of the floor and sides of the groove. Expand
LAT is essential for Fc(epsilon)RI-mediated mast cell activation.
Results show that LAT plays a critical role in Fc(epsilon)RI-mediated signaling in mast cells, and that LAT-deficient mice were resistant to IgE-mediated passive systemic anaphylaxis. Expand