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Structural basis for modulation and agonist specificity of HCN pacemaker channels
The family of hyperpolarization-activated, cyclic nucleotide-modulated (HCN) channels are crucial for a range of electrical signalling, including cardiac and neuronal pacemaker activity, settingExpand
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Biophysical and molecular mechanisms of Shaker potassium channel inactivation
The potassium channels encoded by the Drosophila Shaker gene activate and inactivate rapidly when the membrane potential becomes more positive. Site-directed mutagenesis and single-channelExpand
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Shaker potassium channel gating. III: Evaluation of kinetic models for activation
Predictions of different classes of gating models involving identical conformational changes in each of four subunits were compared to the gating behavior of Shaker potassium channels without N-typeExpand
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Shaker potassium channel gating. II: Transitions in the activation pathway
Voltage-dependent gating behavior of Shaker potassium channels without N-type inactivation (ShB delta 6-46) expressed in Xenopus oocytes was studied. The voltage dependence of the steady-state openExpand
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Two types of inactivation in Shaker K+ channels: Effects of alterations in the carboxy-terminal region
Shaker potassium channels inactivate and recover from inactivation with multiple exponential components, suggesting the presence of multiple inactivation processes. We describe two different types ofExpand
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CNG and HCN channels: two peas, one pod.
Cyclic nucleotide-activated ion channels play a fundamental role in a variety of physiological processes. By opening in response to intracellular cyclic nucleotides, they translate changes inExpand
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Shaker potassium channel gating. I: Transitions near the open state
Kinetics of single voltage-dependent Shaker potassium channels expressed in Xenopus oocytes were studied in the absence of fast N-type inactivation. Comparison of the single-channel first latencyExpand
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Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB
Site-directed mutagenesis experiments have suggested a model for the inactivation mechanism of Shaker potassium channels from Drosophila melanogaster. In this model, the first 20 amino acids form aExpand
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Structure and function of cyclic nucleotide-gated channels.
Cyclic nucleotide-gated (CNG) channels play important roles in both visual (Yau & Baylor 1989) and olfactory (Zufall et al 1994) signal transduction. The cloning of the gene coding for a rodExpand
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Localization of regions affecting an allosteric transition in cyclic nucleotide-activated channels
Sensory transduction in olfactory receptors and photoreceptors is mediated by cyclic nucleotide-activated ion channels. We have studied the gating mechanism in olfactory and rod channels expressed inExpand
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