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Analysis of the molecular specificities of anti-class II monoclonal antibodies by using L cell transfectants expressing HLA class II molecules.
Transfectants expressing human class II molecules should be valuable reagents for studies of B cell and T cell defined epitopes on these molecules.
Single amino acid changes in DR and antigen define residues critical for peptide-MHC binding and T cell recognition.
The observed pattern of complementation led to a model that predicts that the Ag assumes an extended conformation, with a turn, in the binding groove, such that the following residues are in close proximity: DR 86-HA 309, DR 71-HA 312, DR 30-HA 314, and 315.
Molecular cloning and sequence analysis of follicle-stimulating hormone beta polypeptide precursor cDNA from the bovine pituitary gland.
It is indicated that the bovine FSHB gene transcribes at least two classes of mRNA in the wild-type and four classes of RNA in the mutation-bearing individuals, which provides a new insight into the bOVine F SHB evolutionary pattern.
Antigen-specific T cells with monogamous or promiscuous restriction patterns are sensitive to different HLA-DR beta chain substitutions.
- R. Karr, P. Panina-Bordignon, W. Yu, A. Lanzavecchia
- Biology, MedicineJournal of immunology
- 15 June 1991
Interestingly, substitutions at positions 4 and 25, which are predicted in the class II model to be located outside the peptide binding groove, decreased the ability of the DR7 molecule to present Ag to some clones but not to others, emphasize the complexity of the interactions of multiple residues in DR7 beta 1 chains in Ag-specific T cell recognition.
N-terminal functional region of the invariant chain efficiently targets the binding of a CTL epitope to MHC class I molecules during cross-presentation.
- C. Wu, D. G. Zhang, F. Chen, X. Liu, S. J. Liu, W. Yu
- BiologyGenetics and molecular research : GMR
- 3 April 2014
The N-terminal functional region of the Ii fusion protein containing CTL epitopes might prove to be useful for developing peptide or DNA vaccines that use CP as the main mechanism for CD8(+) T cell stimulation.
The role of polymorphic HLA-DR beta chain residues in presentation of viral antigens to T cells
- R. Karr, W. Yu, R. Watts, K. S. Evans, E. Celis
- Biology, MedicineThe Journal of experimental medicine
- 1 July 1990
The results indicate that multiple amino acids, located in both the beta-strands and alpha-helix of DR7 beta 1 in the model of a class II molecule, are involved in DR7- restricted T cell recognition of these antigens, and raises the possibility that the G11.3 peptide may bind to the DR7 molecule in more than one conformation.
DRw11 haplotypes: continuum of DRB1 diversity augmented by unique DQ/DRw52 associations.
A newly characterized HLA-DP beta-chain allele. Evidence for DP beta heterogeneity within the DPw4 specificity.
The patterns of sequence identities and differences among the DPw 4b beta-, DPw4a beta', DPw2 beta-, and DPw3 beta-chains suggest that theDPw4b beta sequence arose via a gene conversion event or a point mutation, and provides the first evidence for structural heterogeneity within the DPW4 specificity.
Polymorphic HLA-DR7 beta 1 chain residues that are involved in T cell allorecognition.
Data indicate that multiple polymorphic residues, predicted in the class II model to be located in both the beta-strands and alpha-helix of the DR7 beta 1 chain, contribute to allorecognition of theDR7 molecule.