• Publications
  • Influence
A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study.
TLDR
It is concluded that in patients with acute spinal-cord injury, treatment with methylprednisolone in the dose used in this study improves neurologic recovery when the medication is given in the first eight hours. Expand
International Standards for Neurological and Functional Classification of Spinal Cord Injury
TLDR
International Standards for Neurological and Functional Classification of Spinal Cord Injury are published and will be used for clinical practice. Expand
Administration of Methylprednisolone for 24 or 48 Hours or Tirilazad Mesylate for 48 Hours in the Treatment of Acute Spinal Cord Injury: Results of the Third National Acute Spinal Cord Injury
TLDR
Patients who received the 48-hour methylprednisolone regimen and who started treatment at 3 to 8 hours were more likely to improve 1 full neurologic grade and show improved motor recovery at 6 weeks and 6 months after injury. Expand
Spinal cord contusion models.
  • W. Young
  • Medicine
  • Progress in brain research
  • 2002
TLDR
The MASCIS Impactor is a well-standardized rat spinal cord contusion model that produces very consistent graded spinal cord damage that linearly predicts 24-h lesion volumes, 6-week white matter sparing, and locomotor recovery in rats. Expand
The Second National Acute Spinal Cord Injury Study.
TLDR
The study strongly suggests that methylprednisolone has significant beneficial effects in human spinal cord injury, that these effects occur only when the drug is given within 8 hr, and that it helps even in patients with severe spinal cord injuries. Expand
Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury
TLDR
Patients with acute spinal cord injury who receive methylprednisolone within 3 hours of injury should be maintained on the treatment regimen for 24 hours, and patients treated with tirilazad for 48 hours showed motor recovery rates equivalent to patients who received methylpredisonsolone for 24Hours. Expand
MASCIS evaluation of open field locomotor scores: effects of experience and teamwork on reliability. Multicenter Animal Spinal Cord Injury Study.
TLDR
Results indicate that inexperienced observers can learn quickly to assign consistent BBB scores that approach those given by experienced teams, that the scores are most consistent between 4 and 16, and that experience improves consistency of team scores. Expand
Endogenous Repair after Spinal Cord Contusion Injuries in the Rat
TLDR
Observations suggest that the endogenous reparative response to spinal contusion injury is substantial, and the regulation and restrictions on the repair processes might lead to better ways in which to encourage spontaneous recovery after CNS injury. Expand
Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial.
TLDR
For patients in whom MP therapy is initiated within 3 hours of injury, 24-hour maintenance is appropriate and patients starting therapy 3 to 8 hours after injury should be maintained on the regimen for 48 hours unless there are complicating medical factors. Expand
The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats.
TLDR
Methylprednisolone and GM1 were compared in a graded rat spinal cord contusion model and it was proposed that the neuroprotective effects of MP are partially due to anti-inflammatory effects and that GM1 antagonizes the effects ofMP by inhibiting lipocortin. Expand
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