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Introduction to heat transfer
Expression of complement components and inhibitors on platelet microparticles
The first evidence for the ability of PMP to support in situ complement activation is provided, based on size, Annexin V binding, and expression of P-selectin and GPIIb.
Complement activation on platelets: implications for vascular inflammation and thrombosis.
Platelet activation in a circulating flow loop: combined effects of shear stress and exposure time
The results show that low-level platelet activation caused by shear stress in a circulation loop can be quantitatively assessed in near-real time in a system of tube geometry and confirm previous results obtained in non-circulating systems that exposure of platelets to shear conditions on the same order as found in the vasculature causes significant plateletactivation.
Blood platelets activate the classical pathway of human complement
- E. Peerschke, W. Yin, S. Grigg, B. Ghebrehiwet
- BiologyJournal of thrombosis and haemostasis : JTH
- 1 September 2006
These data provide the first evidence for C1q dependent classical complement pathway activation on platelets, and support a role for gC1qR/p33 in this process.
Serum complement activation on heterologous platelets is associated with arterial thrombosis in patients with systemic lupus erythematosus and antiphospholipid antibodies
- E. Peerschke, W. Yin, D. Alpert, Ras Roubey, J. Salmon, B. Ghebrehiwet
- Medicine, BiologyLupus
- 24 April 2009
Sera from patients with aPL possess an enhanced capacity for in-situ complement fixation on platelets, which may influence arterial thrombosis risk in patients with SLE.
Flow-Induced Platelet Activation in Bileaflet and Monoleaflet Mechanical Heart Valves
- W. Yin, Y. Alemu, K. Affeld, J. Jesty, D. Bluestein
- Biology, EngineeringAnnals of Biomedical Engineering
- 1 August 2004
Turbent flow patterns were evident in CFD simulations for both valves, and corroborated the PAS observations, showing that, for particles close to the leaflet(s), shear-stress exposure in the bileaflet MHV can be more than four times that in the monoleaflet valve.
Examination of platelet function in whole blood under dynamic flow conditions with the cone and plate(let) analyzer: effect of erythrocytosis and thrombocytosis.
- E. Peerschke, R. Silver, B. Weksler, W. Yin, B. Bernhardt, D. Varon
- MedicineAmerican journal of clinical pathology
- 1 March 2007
It is interesting that differences in CPA AS were discerned among subgroups of patients with MPD undergoing different treatment regimens, and suggest that CPA platelet deposition patterns may provide novel insight into global platelet function during hemodynamic flow.
Flow induced platelet activation in mechanical heart valves - in vitro studies
- W. Yin, D. Bluestein, J. Jestyz, P. Perrotta
- Medicine, BiologyProceedings of the Second Joint 24th Annual…
- 23 October 2002
The platelet activation increased as a function of the recirculation time past the valve, and the restricted valve had a higher activation rate as compared to controls.
Biofluid mechanics : an introduction to fluid mechanics, macrocirculation, and microcirculation
This new second edition increases the breadth and depth of the original by expanding chapters to cover additional biofluid mechanics principles, disease criteria, and medical management of disease, with supporting discussions of the relevance and importance of current research.