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Antiviral flavonoids from the root bark of Morus alba L.
A prenylated flavonoid, moralbanone, along with seven known compounds kuwanon S, mulberroside C, cyclomorusin, eudraflavone B hydroperoxide, oxydihydromorusin, leachianone G and alpha-acetyl-amyrinExpand
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Betulinic Acid and its Derivatives as Potential Antitumor Agents
  • D. Zhang, H. Xu, +6 authors W. Ye
  • Chemistry, Medicine
  • Medicinal research reviews
  • 1 November 2015
Betulinic acid (BA) is a lupane‐type pentacyclic triterpene, distributed ubiquitously throughout the plant kingdom. BA and its derivatives demonstrate multiple bioactivities, particularly anExpand
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Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway.
Hepatocellular carcinoma (HCC) is a deadly form of cancer without effective chemotherapy so far. Currently, only sorafenib, a multitargeted tyrosine kinase inhibitor, slightly improves survival inExpand
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Phenolic compounds from Origanum vulgare and their antioxidant and antiviral activities.
In the present study, six new phenolic compounds (1-6) along with five known ones were isolated from the ethanol extract of the whole plants of Origanum vulgare. The structures of the new compoundsExpand
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Techniques for extraction and isolation of natural products: a comprehensive review
This paper intends to provide a comprehensive view of a variety of methods used in the extraction and isolation of natural products. Expand
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23-Hydroxybetulinic acid-mediated apoptosis is accompanied by decreases in bcl-2 expression and telomerase activity in HL-60 Cells.
23-Hydroxybetulinic acid, a derivative of betulinic acid, was investigated for its apoptotic effect and the associated telomerase activity in human leukemia HL-60 cells. Apoptosis and bcl-2 wereExpand
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BBA, a derivative of 23-hydroxybetulinic acid, potently reverses ABCB1-mediated drug resistance in vitro and in vivo.
23-O-(1,4'-Bipiperidine-1-carbonyl)betulinic acid (BBA), a synthetic derivative of 23-hydroxybetulinic acid (23-HBA), shows a reversal effect on multidrug resistance (MDR) in our preliminaryExpand
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Saxifragifolin B from Androsace umbellata induced apoptosis on human hepatoma cells.
Bioassay-guided phytochemical study of Androsace umbellata led to the successful isolation of saxifragifolin B (SB) for the first time. The anti-tumor effect of SB was firstly reported that it wasExpand
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Apoptotic activity of betulinic acid derivatives on murine melanoma B16 cell line.
The mitochondrion plays a crucial role in the process of apoptosis and has thus become one of the targets for the search for potential chemotherapeutic agents. Betulinic acidExpand
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Cyclodepsipeptides from the ascocarps and insect-body portions of fungus Cordyceps cicadae.
A new cyclodepsipeptide cordycecin A (1), together with four known ones beauvericin E (2), beauvericin J (3), beauvericin (4), and beauvericin A (5) was isolated from the ascocarps and insect-bodyExpand
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