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- Influence
Antiviral flavonoids from the root bark of Morus alba L.
A prenylated flavonoid, moralbanone, along with seven known compounds kuwanon S, mulberroside C, cyclomorusin, eudraflavone B hydroperoxide, oxydihydromorusin, leachianone G and alpha-acetyl-amyrin… Expand
Betulinic Acid and its Derivatives as Potential Antitumor Agents
Betulinic acid (BA) is a lupane‐type pentacyclic triterpene, distributed ubiquitously throughout the plant kingdom. BA and its derivatives demonstrate multiple bioactivities, particularly an… Expand
Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway.
- D. Zhang, Jun-shan Liu, +8 authors W. Ye
- Chemistry, Medicine
- Carcinogenesis
- 1 June 2013
Hepatocellular carcinoma (HCC) is a deadly form of cancer without effective chemotherapy so far. Currently, only sorafenib, a multitargeted tyrosine kinase inhibitor, slightly improves survival in… Expand
Phenolic compounds from Origanum vulgare and their antioxidant and antiviral activities.
- Xiao-li Zhang, Yu-Shan Guo, +6 authors G. Wang
- Chemistry, Medicine
- Food chemistry
- 1 June 2014
In the present study, six new phenolic compounds (1-6) along with five known ones were isolated from the ethanol extract of the whole plants of Origanum vulgare. The structures of the new compounds… Expand
Techniques for extraction and isolation of natural products: a comprehensive review
TLDR
23-Hydroxybetulinic acid-mediated apoptosis is accompanied by decreases in bcl-2 expression and telomerase activity in HL-60 Cells.
- Z. Ji, W. Ye, G. Liu, W. L. Hsiao
- Biology, Medicine
- Life sciences
- 22 November 2002
23-Hydroxybetulinic acid, a derivative of betulinic acid, was investigated for its apoptotic effect and the associated telomerase activity in human leukemia HL-60 cells. Apoptosis and bcl-2 were… Expand
BBA, a derivative of 23-hydroxybetulinic acid, potently reverses ABCB1-mediated drug resistance in vitro and in vivo.
23-O-(1,4'-Bipiperidine-1-carbonyl)betulinic acid (BBA), a synthetic derivative of 23-hydroxybetulinic acid (23-HBA), shows a reversal effect on multidrug resistance (MDR) in our preliminary… Expand
Saxifragifolin B from Androsace umbellata induced apoptosis on human hepatoma cells.
- D. Zhang, Y. Wang, +4 authors K. Fung
- Medicine, Biology
- Biochemical and biophysical research…
- 26 October 2007
Bioassay-guided phytochemical study of Androsace umbellata led to the successful isolation of saxifragifolin B (SB) for the first time. The anti-tumor effect of SB was firstly reported that it was… Expand
Apoptotic activity of betulinic acid derivatives on murine melanoma B16 cell line.
- Wing-keung Liu, J. Ho, F. W. K. Cheung, B. L. Liu, W. Ye, C. Che
- Chemistry, Medicine
- European journal of pharmacology
- 13 September 2004
The mitochondrion plays a crucial role in the process of apoptosis and has thus become one of the targets for the search for potential chemotherapeutic agents. Betulinic acid… Expand
Cyclodepsipeptides from the ascocarps and insect-body portions of fungus Cordyceps cicadae.
A new cyclodepsipeptide cordycecin A (1), together with four known ones beauvericin E (2), beauvericin J (3), beauvericin (4), and beauvericin A (5) was isolated from the ascocarps and insect-body… Expand