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Antiviral flavonoids from the root bark of Morus alba L.
A prenylated flavonoid, moralbanone, along with seven known compounds, including leachianone G and alpha-acetyl-amyrin, were isolated from the root bark of Morus alba L and showed potent antiviral activity and weak activity against herpes simplex type 1 virus. Expand
Techniques for extraction and isolation of natural products: a comprehensive review
This paper intends to provide a comprehensive view of a variety of methods used in the extraction and isolation of natural products, presenting the advantage, disadvantage and practical examples of conventional and modern techniques involved in natural products research. Expand
Betulinic Acid and its Derivatives as Potential Antitumor Agents
This review critically describes the recent research on isolation, synthesis, and derivatization of BA and its natural analogs betulin and 23‐hydroxybetulinic acid and focuses on the current knowledge of antitumor properties, combination treatments, and pharmacological mechanisms of these compounds. Expand
Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway.
The underlying antineoplastic mechanisms of arenobufagin that involve cross talk between apoptosis and autophagy via inhibition of the PI3K/Akt/mTOR pathway are elucidated. Expand
Phenolic compounds from Origanum vulgare and their antioxidant and antiviral activities.
Six new phenolic compounds along with five known ones were isolated from the ethanol extract of the whole plants of Origanum vulgare, and two new compounds exhibited significant antioxidant activity comparable to that of ascorbic acid. Expand
Cyclodepsipeptides from the ascocarps and insect-body portions of fungus Cordyceps cicadae.
Interestingly, compounds 3-5 showed cytotoxic activity against multiple drug resistant HepG2 cell line (HepG2/ADM) with IC50 value 25-fold more sensitive to doxorubicin. Expand
23-Hydroxybetulinic acid-mediated apoptosis is accompanied by decreases in bcl-2 expression and telomerase activity in HL-60 Cells.
Results showed that 23-hydroxybetulinic acid induced growth arrest and apoptotic cell death in HL-60 cells, and suggested that it may be a potential cytotoxic agent for treatment of cancer. Expand
Characterization and Online Detection of Surfactin Isomers Based on HPLC-MSn Analyses and Their Inhibitory Effects on the Overproduction of Nitric Oxide and the Release of TNF-α and IL-6 in
It was revealed that the surfactin isomers showed strong inhibitory properties on the overproduction of nitric oxide and the release of IL-6 on LPS-induced murine macrophage cell RAW264, which will be very helpful for the development of this novel kind of natural product as new anti-inflammatory agents. Expand
New steroidal saponins and sterol glycosides from Paris polyphylla var. yunnanensis.
Four new steroidal saponins, pariposides A-D (1-4), and two new sterol glycosides, pariposides E-F (5-6), along with eight known steroidal saponins (7-14), two known sterol glycosides (15-16), andExpand
Simultaneous Determination of 10 Bioactive Components of Lophatherum gracile Brongn by HPLC-DAD.
A high-performance liquid chromatography method coupled with diode array detection (HPLC-DAD) was developed and successfully applied for the analysis of 10 bioactive compounds in n samples from different cultivated regions. Expand