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EVIDENCE THAT RENAL PROSTAGLANDIN AND THROMBOXANE PRODUCTION IS STIMULATED IN CHRONIC CYCLOSPORINE NEPHROTOXICITY
Previous reports suggest that cyclosporine (CsA) may have direct effects on arachidonic acid (AA) metabolism in several different tissues. However, the effects of CsA on renal eicosanoid productionExpand
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Obstructive nephropathy in the rat: possible roles for the renin-angiotensin system, prostaglandins, and thromboxanes in postobstructive renal function.
Relief of unilateral ureteral obstruction (UUO) of 24 h duration in rats is followed by severe renal vasoconstriction in the postobstructive kidney (POK). The present study examined possible roles ofExpand
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A micropuncture study of postobstructive diuresis in the rat.
In order to investigate the syndrome of postobstructive diuresis, clearance and micropuncture studies were carried out in rats after relief of 24 hr of bilateral (BUL) or unilateral (UUL) ureteralExpand
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Intrarenal hemodynamics following chronic unilateral ureteral obstruction in the dog.
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Renal function after release of unilateral ureteral obstruction in rats.
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Functional role of thromboxane production by acutely rejecting renal allografts in rats.
We investigated the role of thromboxane in mediating the reduction in renal function and renal blood flow characteristic of acute renal allograft rejection. We transplanted kidneys from Lewis rats toExpand
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Double-blind, placebo-controlled trial of potassium chloride in the treatment of mild hypertension.
Epidemiological and experimental data suggest blood pressure-lowering effects of dietary potassium. A randomized, double-blind clinical trial was used to assess blood pressure response to orallyExpand
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Amphotericin B nephrotoxicity: increased renal resistance and tubule permeability.
Two groups of rats received amphotericin-B (Amp). One group (AA) received a single acute dose of 1 mg/kg i.v. The second (CA) received 10 mg/kg i.p. daily for 4 days. In AA rats, measurements 1 to 5Expand
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Intrarenal mechanisms of salt retention after bile duct ligation in rats.
In order to study renal salt-retaining mechanisms during the early stages of ascites formation, rats were subjected to bile duct ligation. After this procedure, plasma volumes were found to beExpand
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