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Myostatin Induces Cyclin D1 Degradation to Cause Cell Cycle Arrest through a Phosphatidylinositol 3-Kinase/AKT/GSK-3β Pathway and Is Antagonized by Insulin-like Growth Factor 1*
- W. Yang, Y. Zhang, Y. Li, Z. Wu, D. Zhu
- Chemistry, Medicine
- Journal of Biological Chemistry
- 30 November 2006
Myostatin is a transforming growth factor β superfamily member and is known as an inhibitor of skeletal muscle cell proliferation and differentiation. Exposure to myostatin induces G1 phase cell… Expand
Methanotrophic community structure and activity under warming and grazing of alpine meadow on the Tibetan Plateau
- Yong Zheng, W. Yang, +4 authors Liang-Dong Guo
- Biology, Medicine
- Applied Microbiology and Biotechnology
- 1 March 2012
Knowledge about methanotrophs and their activities is important to understand the microbial mediation of the greenhouse gas CH4 under climate change and human activities in terrestrial ecosystems.… Expand
Extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase pathway is involved in myostatin-regulated differentiation repression.
- W. Yang, Y. Chen, Y. Zhang, X. Wang, Ning Yang, D. Zhu
- Medicine, Biology
- Cancer research
- 1 February 2006
The cytokines of transforming growth factor beta (TGF-beta) and its superfamily members are potent regulators of tumorigenesis and multiple cellular events. Myostatin is a member of TGF-beta… Expand
Differential responses of arbuscular mycorrhizal fungi to nitrogen addition in a near pristine Tibetan alpine meadow.
- Yong Zheng, Y. Kim, +6 authors Liang-Dong Guo
- Biology, Medicine
- FEMS microbiology ecology
- 1 September 2014
Elucidating the responses of soil microbial abundance and community composition to nitrogen (N) addition is important for predicting ecosystem function under increased atmospheric N deposition. We… Expand
Volcanic history of the Imbrium basin: A close-up view from the lunar rover Yutu
- J. Zhang, W. Yang, +16 authors Z. Ouyang
- Geography, Medicine
- Proceedings of the National Academy of Sciences
- 13 April 2015
Significance After the Apollo and Luna missions, which were flown about 40 years ago, the Moon was explored only from orbit. In addition, no samples were returned from the young and high-FeO and TiO2… Expand
Liquid chromatography-tandem mass spectrometry-based plasma metabonomics delineate the effect of metabolites' stability on reliability of potential biomarkers.
Metabonomics is an important platform for investigating the metabolites of integrated living systems and their dynamic responses to changes caused by both endogenous and exogenous factors. A… Expand
mamO and mamE genes are essential for magnetosome crystal biomineralization in Magnetospirillum gryphiswaldense MSR-1.
Four non-magnetic mutants of Magnetospirillum gryphiswaldense strain MSR-1 were isolated by transposon mutagenesis and found to contain interruption of either the mamO or mamE gene within the mamAB… Expand
Association study of ACE2 (angiotensin I-converting enzyme 2) gene polymorphisms with coronary heart disease and myocardial infarction in a Chinese Han population.
Results are accumulating that ACE2 (angiotensin I-converting enzyme 2) might act as a protective protein for cardiovascular diseases; however, only a few studies in human populations have been… Expand
BNIP3L/NIX-mediated mitophagy protects against ischemic brain injury independent of PARK2
ABSTRACT Cerebral ischemia induces massive mitochondrial damage. These damaged mitochondria are cleared, thus attenuating brain injury, by mitophagy. Here, we identified the involvement of BNIP3L/NIX… Expand
Identification of a novel human long non-coding RNA that regulates hepatic lipid metabolism by inhibiting SREBP-1c
- Duan Li, Min Cheng, +6 authors W. Yang
- Chemistry, Medicine
- International journal of biological sciences
- 25 February 2017
Sterol regulatory element binding proteins (SREBPs) are master regulators of hepatic lipid homeostasis. Aberrant expression of SREBPs frequently leads to lipid metabolism dysregulation. Long… Expand