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Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
A role for B-cell-receptor (BCR) signalling in lymphomagenesis has been inferred by studying immunoglobulin genes in human lymphomas and by engineering mouse models, but genetic and functionalExpand
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Oncogenically active MYD88 mutations in human lymphoma
The activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) remains the least curable form of this malignancy despite recent advances in therapy. Constitutive nuclear factorExpand
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Oncogenic CARD11 Mutations in Human Diffuse Large B Cell Lymphoma
Diffuse large B cell lymphoma (DLBCL) is the most common form of non-Hodgkin's lymphoma. In the least curable (ABC) subtype of DLBCL, survival of the malignant cells is dependent on constitutiveExpand
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IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates
During endoplasmic reticulum (ER) stress, homeostatic signaling through the unfolded protein response (UPR) augments ER protein-folding capacity. If homeostasis is not restored, the UPR triggersExpand
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Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics
Burkitt’s lymphoma (BL) can often be cured by intensive chemotherapy, but the toxicity of such therapy precludes its use in the elderly and in patients with endemic BL in developing countries,Expand
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Genetics and Pathogenesis of Diffuse Large B‐Cell Lymphoma
Background Diffuse large B‐cell lymphomas (DLBCLs) are phenotypically and genetically heterogeneous. Gene‐expression profiling has identified subgroups of DLBCL (activated B‐cell–like [ABC],Expand
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A genomic storm in critically injured humans
Critical injury in humans induces a genomic storm with simultaneous changes in expression of innate and adaptive immunity genes.
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Genomic responses in mouse models poorly mimic human inflammatory diseases
A cornerstone of modern biomedical research is the use of mouse models to explore basic pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no-go decisions to carry newExpand
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The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment
Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibilityExpand
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Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma.
Knowledge of oncogenic mutations can inspire therapeutic strategies that are synthetically lethal, affecting cancer cells while sparing normal cells. Lenalidomide is an active agent in the activatedExpand
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