A RIPK3-PGE2 Circuit Mediates Myeloid-Derived Suppressor Cell-Potentiated Colorectal Carcinogenesis.
- Guifang Yan, Huakan Zhao, Yongsheng Li
- Biology, MedicineCancer Research
- 16 July 2018
A novel signaling circuit involving RIPK3 and PGE2 enhances accumulation and immunosuppressive activity of MDSCs, implicating its potential as a therapeutic target in anticancer immunotherapy and providing potential ideas for immunotherapy against colorectal cancer.
Aryl Hydrocarbon Receptor Activation Modulates Intestinal Epithelial Barrier Function by Maintaining Tight Junction Integrity
- Min Yu, Qimeng Wang, Hua Yang
- Medicine, BiologyInternational Journal on Biological Sciences
- 11 January 2018
It is found that AhR activation by FICZ attenuated the decreased TJ protein expression in the colonic mucosa of the DSS-induced mice, and AhR-activating factors might have potential as therapeutic agents for the treatment of patients with IBD.
Involvement of miR-20a in Promoting Gastric Cancer Progression by Targeting Early Growth Response 2 (EGR2)
- Xiangsheng Li, Zhichao Zhang, Hua Yang
- BiologyInternational Journal of Molecular Sciences
- 1 August 2013
Gastric cancer (GC) is one of the most common cancers, with high incidences in East Asia. microRNAs (miRNAs) play essential roles in the carcinogenesis of GC. miR-20a was elevated in GC, while the…
GDNF is Involved in the Barrier-Inducing Effect of Enteric Glial Cells on Intestinal Epithelial Cells Under Acute Ischemia Reperfusion Stimulation
- W. Xiao, Wensheng Wang, Hua Yang
- BiologyMolecular Neurobiology
- 31 May 2014
It is reported that EGCs are closely involved in the modulation of IEB functions in response to IR challenge, and GDNF plays an important role in the barrier-protective mechanism of activated E GCs under IR stimulation, whereas EGC’s are also involved in intestinal inflammation response, which may contribute to IEB damage induced by IR injury.
Aryl Hydrocarbon Receptor Activation Down-Regulates IL-7 and Reduces Inflammation in a Mouse Model of DSS-Induced Colitis
6-formylindolo (3,2-b) carbazole (Ficz) could down-regulate epithelial-derived IL-7 expression in mice with DSS-induced colitis and inhibit inflammation in the gastrointestinal tract of mice.
The AhR is involved in the regulation of LoVo cell proliferation through cell cycle‐associated proteins
- Jiuheng Yin, B. Sheng, Hua Yang
- Biology, ChemistryCell Biology International
- 1 May 2016
It is concluded that the AhR, when activated by FICZ (an endogenous AhR ligand), can arrest the cell cycle and block LoVo cell proliferation.
Aryl Hydrocarbon Receptor Activation in Intestinal Obstruction Ameliorates Intestinal Barrier Dysfunction Via Suppression of MLCK-MLC Phosphorylation Pathway
- Bin-ze Han, B. Sheng, Hua Yang
- Medicine, BiologyShock
- 1 September 2016
AhR activation can ameliorate epithelial barrier dysfunction induced by IO through the suppression of MLCK-pMLC signaling, suggesting that AhR agonist may be a suitable means of addressing this condition.
Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition
- Yongjia Feng, Farokh R. Demehri, P. Dempsey
- MedicineCellular and Molecular Gastroenterology and…
- 17 January 2017
Screening and combining serum biomarkers to improve their diagnostic performance in the detection of intestinal barrier dysfunction in patients after major abdominal surgery.
- C. Kong, Shumin Li, Pengyuan Xu
- MedicineAnnals of Translational Medicine
- 1 August 2019
The combination of serum D-lactic acid, citrulline and I-FABP greatly improved the diagnostic performance for identifying intestinal barrier dysfunction in patients after major abdominal surgery.
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