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Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy.
- Zhenlin Zhang, W. Xia, +11 authors Yu-juan Liu
- Biology, Medicine
- American journal of human genetics
- 13 January 2012
By using whole-exome sequencing, we identified a homozygous guanine-to-adenine transition at the invariant -1 position of the acceptor site of intron 1 (c.97-1G>A) in solute carrier organic anion… Expand
An updated hip fracture projection in Asia: The Asian Federation of Osteoporosis Societies study
Objectives Hip fracture is a major public health problem. Earlier studies projected that the total number of hip fracture will increase dramatically by 2050, and most of the hip fracture will occur… Expand
Myostatin regulates glucose metabolism via the AMP-activated protein kinase pathway in skeletal muscle cells.
- Yue-Wen Chen, J. Ye, Lingzhi Cao, Y. Zhang, W. Xia, D. Zhu
- Biology, Medicine
- The international journal of biochemistry & cell…
- 1 December 2010
Myostatin (Mstn) is a secreted growth factor predominately expressed in skeletal muscle that negatively regulates skeletal muscle mass. Recent studies have indicated that loss function of myostatin… Expand
Three Novel Mutations of the PHEX Gene in Three Chinese Families with X-linked Dominant Hypophosphatemic Rickets
- W. Xia, X. Meng, +9 authors Xueying Zhou
- Medicine, Biology
- Calcified Tissue International
- 29 November 2007
X-linked dominant hypophosphatemia (XLH, OMIM307800), the most prevalent form of inherited rickets in humans, is a dominant disorder of phosphate homeostasis characterized by growth retardation,… Expand
Identification of suitable reference gene and biomarkers of serum miRNAs for osteoporosis
Our objective was to identify suitable reference genes in serum miRNA for normalization and screen potential new biomarkers for osteoporosis diagnosis by a systematic study. Two types of osteoporosis… Expand
Factors influencing diagnosis and treatment of osteoporosis after a fragility fracture among postmenopausal women in Asian countries: a retrospective study
BackgroundA vast amount of literature describes the incidence of fracture as a risk for recurrent osteoporotic fractures in western and Asian countries. Osteoporosis evaluation and treatment after a… Expand
FGF23 and Phosphate Wasting Disorders
A decade ago, only two hormones, parathyroid hormone and 1,25(OH)2D, were widely recognized to directly affect phosphate homeostasis. Since the discovery of fibroblast growth factor 23 (FGF23) in… Expand
Chinese Bone Turnover Marker Study: Reference Ranges for C-Terminal Telopeptide of Type I Collagen and Procollagen I N-Terminal Peptide by Age and Gender
Background Bone formation marker procollagen I N-terminal peptide (PINP) and resorption marker C-terminal telopeptide of type I collagen (β-CTX) are useful biomarkers for differential diagnosis and… Expand
Hyperthyroidism caused by an ectopic thyrotropin-secreting tumor of the nasopharynx: a case report and review of the literature.
- Anli Tong, W. Xia, +6 authors Xiaolan Lian
- Thyroid : official journal of the American…
- 9 September 2013
BACKGROUND Ectopic thyrotropin (TSH)-secreting tumors are extremely rare. To our knowledge, only three cases have previously been reported so far, but the tumors were not studied ultrastructurally… Expand
Novel mutations of CYP27B1 gene lead to reduced activity of 1α-hydroxylase in Chinese patients.
Pseudovitamin D-deficiency rickets (PDDR) is an autosomal recessive disorder resulting from a defect in renal 25-hydroxyvitamin D 1α-hydroxylase, the key enzyme in the pathway of vitamin D… Expand