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The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.
Proapoptotic Bcl-2 family members have been proposed to play a central role in regulating apoptosis. However, mice lacking bax display limited phenotypic abnormalities. As presented here, bak(-/-)… Expand
p73 Induces Apoptosis via PUMA Transactivation and Bax Mitochondrial Translocation*
- G. Melino, F. Bernassola, +7 authors K. Vousden
- Biology, Medicine
- Journal of Biological Chemistry
- 27 February 2004
p73, an important developmental gene, shares a high sequence homology with p53 and induces both G1 cell cycle arrest and apoptosis. However, the molecular mechanisms through which p73 induces… Expand
The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis.
Bcl-2-family proteins are key regulators of the apoptotic response. Here, we demonstrate that the pro-survival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB. We show that… Expand
Rel/NF‐κB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors
Jagged1 belongs to the DSL family of ligands for Notch receptors that control the proliferation and differentiation of various cell lineages. However, little is known about the transcription factors… Expand
c-Rel arrests the proliferation of HeLa cells and affects critical regulators of the G1/S-phase transition.
A tetracycline-regulated system was used to characterize the effects of c-Rel on cell proliferation. The expression of c-Rel in HeLa cells led to growth arrest at the G1/S-phase transition, which… Expand
The Ser36-Ser37 Pair in HeLa Nuclear Protein p21/SIIR Mediates Ser/Thr Phosphorylation and Is Essential for Rous Sarcoma Virus Long Terminal Repeat Repression (*)
- C. H. Yeh, W. X. Zong, A. Shatkin
- Biology, Medicine
- The Journal of Biological Chemistry
- 27 October 1995
Phosphorylation of HeLa SII (or TFIIS)-related nuclear protein p21/SIIR was demonstrated in transfected COS-1 cells. To test for a possible functional link between phosphorylation and the previously… Expand
J . Biol . Chem . 23-10-2003 p 73 induces apoptosis via PUMA transactivation and Bax mitochondrial translocation
Biochemistry Laboratory, IDI-IRCCS, Department of Experimental Medicine and Biochemical Sciences, University of Rome "Tor Vergata", 00133 Rome, Italy. MRC toxicology Unit, University of Leicester,… Expand
N-terminal determinants of I kappa B alpha necessary for the cytoplasmic regulation of c-Rel.
I kappa B alpha is a dual regulator of Rel/NF-kappa B transcription factors. I kappa B alpha retains inactive NF-kappa B dimers in the cytoplasm, and inhibits their DNA-binding and transcriptional… Expand