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Neural plate patterning: Upstream and downstream of the isthmic organizer
TLDR
Current knowledge on the identity, localization and maintenance of the isthmic organizer, as well as on the molecular cascades that underlie the activity of this organizing centre are reviewed. Expand
Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells
TLDR
E1B55K and E4orf6 improved the efficiency of HDR up to eightfold and essentially abolished NHEJ activity in both human and mouse cell lines and provide useful tools to improve the frequency of precise gene modifications in mammalian cells. Expand
Arc/Arg3.1 Is Essential for the Consolidation of Synaptic Plasticity and Memories
TLDR
A critical role is demonstrated in the consolidation of enduring synaptic plasticity and memory storage in Arc/Arg3.1 knockout mice that fail to form long-lasting memories for implicit and explicit learning tasks, despite intact short-term memory. Expand
Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation.
TLDR
Two distinct lineage boundaries in mouse ectoderm prior to limb bud outgrowth are identified using a Cre/loxP-based fate-mapping approach and a novel retroviral cell-labeling technique and fate mapping of AER domains in mutants showed that En1 plays a part in positioning and maintaining the two lineage borders. Expand
The caudal limit of Otx2 expression positions the isthmic organizer
TLDR
Findings show that the caudal limit of Otx2 expression is sufficient for positioning the isthmic organizer and encoding caUDal midbrain fate within the mid/hindbrain domain. Expand
The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum
TLDR
The data show that Fgf8 is part of a complex gene regulatory network that is essential for cell survival in the mes/met, and a remarkably similar pattern of cell death in Wnt1 null homozygotes, is observed. Expand
A Humanized Version of Foxp2 Affects Cortico-Basal Ganglia Circuits in Mice
TLDR
In the striatum, a part of the basal ganglia affected in humans with a speech deficit due to a nonfunctional FOXP2 allele, it is found that medium spiny neurons have increased dendrite lengths and increased synaptic plasticity, suggesting that alterations in cortico-basal ganglia circuits might have been important for the evolution of speech and language in humans. Expand
Fate of Midbrain Dopaminergic Neurons Controlled by the Engrailed Genes
TLDR
Findings show that the engrailed genes are expressed by midbrain dopaminergic neurons from their generation to adulthood but are not required for their specification, and suggest a link between En-1 and En-2 and Parkinson's disease. Expand
Inducible gene deletion in astroglia and radial glia—A valuable tool for functional and lineage analysis
TLDR
It is shown that the inducible form of Cre (CreERT2) expressed in the locus of the astrocyte‐specific glutamate transporter (GLAST) allows precisely timed gene deletion in adultAstrocytes as well as radial glial cells at earlier developmental stages. Expand
The mouse Engrailed-1 gene and ventral limb patterning
TLDR
It is reported that Engrailed-1, a homeodomain-containing transcription factor expressed in embryonic ventral limb ectoderm7–8, is essential forventral limb patterning and isessential for proper formation of the apical ectodermal ridge. Expand
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