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Monolayer-protected cluster molecules.
In this report, we evaluate the present state of the rapidly emerging field of monolayer-protected cluster (MPC) molecules with regard to their synthesis and monolayer functionalization, their coreExpand
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Nanometer Gold Clusters Protected by Surface-Bound Monolayers of Thiolated Poly(ethylene glycol) Polymer Electrolyte
W. Peter Wuelfing, Stephen M. Gross, Deon T. Miles, andRoyce W. Murray*Kenan Laboratories of ChemistryUniVersity of North CarolinaChapel Hill, North Carolina 27599-3290ReceiVed September 8, 1998MetalExpand
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Mechanism of Dissolution-Induced Nanoparticle Formation from a Copovidone-Based Amorphous Solid Dispersion.
Amorphous solid dispersions (ASDs) have been increasingly used to maximize human exposures from poorly soluble drug candidates. One well-studied advantage of ASDs is the increased amorphous drugExpand
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Polysorbate 80 UV/vis spectral and chromatographic characteristics--defining boundary conditions for use of the surfactant in dissolution analysis.
Polysorbate 80 is used in the pharmaceutical industry as an additive to enhance the solubility of non-polar compounds in formulation design and during dissolution analysis. In this paper we presentExpand
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Taylor dispersion measurements of monolayer protected clusters : A physicochemical determination of nanoparticle size
We describe the use of the Taylor dispersion method to determine the diffusion coefficients of monolayer protected clusters (MPCs). The MPCs have nanometer Au cores (∼1−5 nm diameter) coated with aExpand
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Electron Hopping through Films of Arenethiolate Monolayer-Protected Gold Clusters
Electron hopping in films of arenethiolate (benzylthiolate, phenylethylthiolate, phenylbutanethiolate, and cresolthiolate) monolayer-protected cluster molecules (MPCs) is investigated throughExpand
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Profiling of medium chain glycerides used in pharmaceutical formulation development by reversed-phase HPLC.
Medium chain length (C8, C10) mono-, di- and triacylglycerols (MCGs) are used in pharmaceutical formulation development of poorly soluble compounds, as a means to increase their oral bioavailability.Expand
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Iron(III)-Mediated Oxidative Degradation on the Benzylic Carbon of Drug Molecules in the Absence of Initiating Peroxides.
Metal ions play an important role in oxidative drug degradation. One of the most ubiquitous metal ion impurities in excipients and buffers is Fe(III). In the field of oxidative drug degradationExpand
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Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists.
In an ongoing effort to explore the use of orexin receptor antagonists for the treatment of insomnia, dual orexin receptor antagonists (DORAs) were structurally modified, resulting in compoundsExpand
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Detection and quantification of low-molecular-weight aldehydes in pharmaceutical excipients by headspace gas chromatography.
The adverse effect of reactive chemical residues on the quality of drug products has necessitated the determination of low-molecular-weight aldehydes in pharmaceutical excipients. An analyticalExpand
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