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Necroptosis: an emerging form of programmed cell death.
Necrosis plays an important role in multiple physiological and pathological processes. Recently, a relatively new form of necrosis has been characterized as "necroptosis". Morphologically,… Expand
Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data.
- W. Wu, E. Bleecker, +9 authors S. Wenzel
- The Journal of allergy and clinical immunology
- 1 May 2014
BACKGROUND Previous studies have identified asthma phenotypes based on small numbers of clinical, physiologic, or inflammatory characteristics. However, no studies have used a wide range of variables… Expand
MiR-223 Suppresses Cell Proliferation by Targeting IGF-1R
To study the roles of microRNA-223 (miR-223) in regulation of cell growth, we established a miR-223 over-expression model in HeLa cells infected with miR-223 by Lentivirus pLL3.7 system. We observed… Expand
miR-10a inhibits dendritic cell activation and Th1/Th17 cell immune responses in IBD
Objective Although both innate and adaptive responses to microbiota have been implicated in the pathogenesis of IBD, it is still largely unknown how they are regulated during intestinal inflammation.… Expand
Effect of superposed electromagnetic noise on DNA damage of lens epithelial cells induced by microwave radiation.
- K. Yao, W. Wu, +4 authors Kaijun Wang
- Biology, Medicine
- Investigative ophthalmology & visual science
- 1 May 2008
PURPOSE To investigate the influence of the 1.8-GHz radiofrequency fields (RFs) of the Global System for Mobile Communications on DNA damage, intracellular reactive oxygen species (ROS) formation,… Expand
Systematic Review of HIV Transmission between Heterosexual Serodiscordant Couples where the HIV-Positive Partner Is Fully Suppressed on Antiretroviral Therapy
Background The risk of sexual HIV transmission in serodiscordant couples when the HIV-positive partner has full virologic suppression on combination antiretroviral therapy (cART) is debated. This… Expand
Mucinous colorectal adenocarcinoma: clinical pathology and treatment options
Mucinous colorectal adenocarcinoma is a distinct subtype of colorectal cancer (CRC) characterized by the presence of abundant extracellular mucin which accounts for at least 50% of the tumor volume.… Expand
Ocular safety of fluticasone furoate nasal spray in patients with perennial allergic rhinitis: a 2-year study.
- C. Laforce, G. E. Journeay, +4 authors L. Chylack
- Annals of allergy, asthma & immunology : official…
- 1 July 2013
BACKGROUND This is the first study, to our knowledge, to evaluate the ocular effects of an intranasal corticosteroid during 2 years of treatment for perennial allergic rhinitis (PAR). OBJECTIVE To… Expand
Genetic variants in TERT-CLPTM1L genetic region associated with several types of cancer: a meta-analysis.
BACKGROUND TERT-CLPTM1L genomic region has been extensively associated with several types of cancer. However, results were inconsistent. We performed this meta-analysis to estimate the association… Expand
ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis
- Jacob Paiano, W. Wu, +8 authors A. Nussenzweig
- Chemistry, Medicine
- Nature Communications
- 12 February 2020
Meiotic recombination is initiated by SPO11-induced double-strand breaks (DSBs). In most mammals, the methyltransferase PRDM9 guides SPO11 targeting, and the ATM kinase controls meiotic DSB numbers.… Expand