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The in vitro metabolism of thalicarpine, an aporphine-benzyltetrahydroisoquinoline alkaloid, in the rat. API-MS/MS identification of thalicarpine and metabolites.
  • W. Wu, L. A. Mckown
  • Chemistry, Medicine
  • Journal of pharmaceutical and biomedical analysis
  • 1 August 2002
TLDR
The proposed metabolic pathways for thalicarpine are proposed, and the three metabolic pathways are: (1) N-demethylation; (2) aporphine ring oxidation; and (3) benzylic oxidation/reduction. Expand
Potential anxiolytic agents. Part 4: novel orally-active N(5)-substituted pyrido[1,2-a]benzimidazoles with high GABA-A receptor affinity.
A series of pyrido[1,2-a]benzimidazoles (PBIs) with substitution on the N(5)-nitrogen has been synthesized and found to possess high affinity for the benzodiazepine (BZD) site on the GABA-A receptor.Expand
Structural Elucidation of Isoquinoline, Isoquinolone, Benzylisoquinoline, Aporphine, and Phenanthrene Alkaloids Using API-ionspray Tandem Mass Spectrometry
API-ionspray MS and MS/MS techniques were utilized to elucidate the structures of twenty-two isoquinoline alkaloids consisting of six simple isoquinolines, three isoquinolones, sevenExpand
The synthesis and evaluation of the major metabolites of mazapertine
Several of the key metabolites of mazapertine, a novel antipyschotic agent, were prepared in order to firmly establish their chemical structure and to obtain samples for biological testing.Expand
In vitro metabolism of the new anxiolytic agent, RWJ-52763 in human hepatic S9 fraction-API-MS/MS identification of metabolites.
TLDR
In vitro metabolism of the anxiolytic agent, RWJ-52763 was studied after incubation with human hepatic S9 fraction in the presence of an NADPH-generating system, and the two metabolic pathways are proposed: N/O-dealkylation, and phenylhydroxylation. Expand
API-ionspray MS and MS/MS study on the structural characterization of bisbenzylisoquinoline alkaloids.
  • W. Wu, M. D. Moyer
  • Chemistry, Medicine
  • Journal of pharmaceutical and biomedical analysis
  • 27 January 2004
API-ionspray MS and MS/MS techniques have been utilized to elucidate the structures of 20 bisbenzylisoquinoline alkaloids, consisting of 17 diether and three monoether links of twoExpand
Electrospray Tandem Mass Spectrometry for Structural Characterization of Aporphine-Benzylisoquinoline Alkaloids
  • W. Wu, M. D. Moyer
  • Chemistry, Medicine
  • European journal of mass spectrometry
  • 1 October 2004
Electrospray mass spectrometry and tandem mass spectrometry techniques were utilized to elucidate the structures of ten aporphine-benzylisoquinoline alkaloids, consisting of a monoether link betweenExpand
N-Alkyl-4-[(8-azabicyclo[3.2.1]-oct-3-ylidene)phenylmethyl]benzamides, μ and δ opioid agonists: a μ address
Abstract The tertiary amide δ opioid agonist 2 is a potent antinociceptive agent. Compound 2 was metabolized in vitro and in vivo to secondary amide 3, a potent and selective μ opioid agonist. TheExpand
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