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The Nematode Caenorhabditis elegans
This "Book of the Worm" serves as a reference source for C. elegans investigators as well as an introductory monograph for other biologists. Expand
Generation of asymmetry and segregation of germ-line granules in early C. elegans embryos
The results suggest that P-granule segregation does not require either the spindle or cytoplasmic microtubules, but that this process as well as generation of other asymmetries does require cytoskeletal functions that depend on microfilaments. Expand
PGL-1, a Predicted RNA-Binding Component of Germ Granules, Is Essential for Fertility in C. elegans
It is shown that a component of germ granules is essential for fertility in C. elegans and that its primary function is in germline proliferation. Expand
Mutations affecting embryonic cell migrations in Caenorhabditis elegans.
Four recessive mutations that affect long-range embryonic migration of the two canal-associated neurons (CANs) in C. elegans were isolated and characterized with the goal of identifying genesExpand
Acute meningitis.
Multiple Wnt signaling pathways converge to orient the mitotic spindle in early C. elegans embryos.
A model for the coordination of cell-cell interactions and distinct Wnt signaling pathways that ensures the robust timing and orientation of spindle rotation during a developmentally regulated cell division event is established. Expand
A BMP homolog acts as a dose-dependent regulator of body size and male tail patterning in Caenorhabditis elegans.
The cloned dbl-1 gene, a C. elegans homolog of Drosophila decapentaplegic and vertebrate BMP genes, suggests a role for neuronal cells in global size regulation as well as male tail patterning. Expand
Immunofluorescence visualization of germ-line-specific cytoplasmic granules in embryos, larvae, and adults of Caenorhabditis elegans.
  • S. Strome, W. Wood
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 March 1982
The P granules are similar in number, size, and distribution to germ-line-specific structures identified as "germinal plasm" by electron microscopy in C. elegans embryos. Expand
Host specificity of DNA produced by Escherichia coli: bacterial mutations affecting the restriction and modification of DNA.
  • W. Wood
  • Biology, Medicine
  • Journal of molecular biology
  • 1 March 1966
Behavior of the mutant strains in conjugation experiments is consistent with the view that bacterial DNA is restricted and modified by the same factors which act upon the DNA of phage λ, and that this restriction is responsible for the abnormally low frequency of recombinant formation observed in K12 × B crosses. Expand
Parental effects and phenotypic characterization of mutations that affect early development in Caenorhabditis elegans.
Genetic tests for parental effects were performed on 24 temperature-sensitive embryonic-lethal mutants of the nematode Caenorhabditis elegans, suggesting that some zygotic genes can function early in embryogenesis. Expand