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Publications Influence

Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection.

Recent advances in cDNA and oligonucleotide DNA arrays have made it possible to measure the abundance of mRNA transcripts for many genes simultaneously. The analysis of such experiments is nontrivial… Expand

3,321 233- PDF

The calculation of posterior distributions by data augmentation

Abstract The idea of data augmentation arises naturally in missing value problems, as exemplified by the standard ways of filling in missing cells in balanced two-way tables. Thus data augmentation… Expand

3,820 194

Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses

- Arindam Bhattacharjee, W. Richards, +16 authors M. Meyerson
- Biology
- Proceedings of the National Academy of Sciences…
- 13 November 2001

We have generated a molecular taxonomy of lung carcinoma, the leading cause of cancer death in the United States and worldwide. Using oligonucleotide microarrays, we analyzed mRNA expression levels… Expand

1,567 81

Sequential Imputations and Bayesian Missing Data Problems

Abstract For missing data problems, Tanner and Wong have described a data augmentation procedure that approximates the actual posterior distribution of the parameter vector by a mixture of complete… Expand

1,055 80- PDF

SIMULATING RATIOS OF NORMALIZING CONSTANTS VIA A SIMPLE IDENTITY: A THEORETICAL EXPLORATION

- Xiao-Li Meng, W. Wong
- Mathematics
- 1996

Let pi(w) ,i =1 , 2, be two densities with common support where each density is known up to a normalizing constant: pi(w )= qi(w)/ci .W e have draws from each density (e.g., via Markov chain Monte… Expand

660 52- PDF

Extensive and divergent circadian gene expression in liver and heart

Many mammalian peripheral tissues have circadian clocks; endogenous oscillators that generate transcriptional rhythms thought to be important for the daily timing of physiological processes. The… Expand

1,400 51- PDF

FoxOs Are Lineage-Restricted Redundant Tumor Suppressors and Regulate Endothelial Cell Homeostasis

- Ji-hye Paik, R. Kollipara, +13 authors R. DePinho
- Biology, Medicine
- Cell
- 26 January 2007

Activated phosphoinositide 3-kinase (PI3K)-AKT signaling appears to be an obligate event in the development of cancer. The highly related members of the mammalian FoxO transcription factor family,… Expand

936 50- PDF

Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia

- Y. Hakak, J. Walker, +5 authors A. Fienberg
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 10 April 2001

Neuropathological and brain imaging studies suggest that schizophrenia may result from neurodevelopmental defects. Cytoarchitectural studies indicate cellular abnormalities suggestive of a disruption… Expand

1,133 48- PDF

Profile Likelihood and Conditionally Parametric Models

- T. Severini, W. Wong
- Mathematics
- 1 December 1992

In this paper, we outline a general approach to estimating the parametric component of a semiparametric model. For the case of a scalar parametric component, the method is based on the idea of first… Expand

303 44

Probability inequalities for likelihood ratios and convergence rates of sieve MLEs

Let Y 1 ,...,Y n be independent identically distributed with density p 0 and let F be a space of densities. We show that the supremum of the likelihood ratios Π i=1 n p(Y i )/p 0 (Y i ), where the… Expand

263 44