• Publications
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Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection.
  • C. Li, W. Wong
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2 January 2001
Recent advances in cDNA and oligonucleotide DNA arrays have made it possible to measure the abundance of mRNA transcripts for many genes simultaneously. The analysis of such experiments is nontrivialExpand
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The calculation of posterior distributions by data augmentation
Abstract The idea of data augmentation arises naturally in missing value problems, as exemplified by the standard ways of filling in missing cells in balanced two-way tables. Thus data augmentationExpand
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Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses
We have generated a molecular taxonomy of lung carcinoma, the leading cause of cancer death in the United States and worldwide. Using oligonucleotide microarrays, we analyzed mRNA expression levelsExpand
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Sequential Imputations and Bayesian Missing Data Problems
Abstract For missing data problems, Tanner and Wong have described a data augmentation procedure that approximates the actual posterior distribution of the parameter vector by a mixture of completeExpand
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SIMULATING RATIOS OF NORMALIZING CONSTANTS VIA A SIMPLE IDENTITY: A THEORETICAL EXPLORATION
Let pi(w) ,i =1 , 2, be two densities with common support where each density is known up to a normalizing constant: pi(w )= qi(w)/ci .W e have draws from each density (e.g., via Markov chain MonteExpand
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Extensive and divergent circadian gene expression in liver and heart
Many mammalian peripheral tissues have circadian clocks; endogenous oscillators that generate transcriptional rhythms thought to be important for the daily timing of physiological processes. TheExpand
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FoxOs Are Lineage-Restricted Redundant Tumor Suppressors and Regulate Endothelial Cell Homeostasis
Activated phosphoinositide 3-kinase (PI3K)-AKT signaling appears to be an obligate event in the development of cancer. The highly related members of the mammalian FoxO transcription factor family,Expand
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Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia
Neuropathological and brain imaging studies suggest that schizophrenia may result from neurodevelopmental defects. Cytoarchitectural studies indicate cellular abnormalities suggestive of a disruptionExpand
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Profile Likelihood and Conditionally Parametric Models
In this paper, we outline a general approach to estimating the parametric component of a semiparametric model. For the case of a scalar parametric component, the method is based on the idea of firstExpand
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Probability inequalities for likelihood ratios and convergence rates of sieve MLEs
Let Y 1 ,...,Y n be independent identically distributed with density p 0 and let F be a space of densities. We show that the supremum of the likelihood ratios Π i=1 n p(Y i )/p 0 (Y i ), where theExpand
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