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Parent bisphenol A accumulation in the human maternal-fetal-placental unit.
- G. Schönfelder, W. Wittfoht, H. Hopp, C. Talsness, M. Paul, I. Chahoud
- MedicineEnvironmental health perspectives
- 10 October 2002
Exposure levels of parent BPA were found within a range typical of those used in recent animal studies and were shown to be toxic to reproductive organs of male and female offspring.
Exposure of newborn infants to di‐(2‐ethylhexyl)‐phthalate and 2‐ ethylhexanoic acid following exchange transfusion with polyvinylchloride catheters
Concentrations of EHXA were lower than anticipated, which indicates that EHZA is not a major metabolite in the neonatal infant, and therefore infants undergoing exchange transfusion are exposed to toxic levels of DEHP and the presumed metabolite 2‐ethylhexanoic acid.
Arginine is a physiological precursor of endothelium-derived nitric oxide.
Identification of 9-cis-retinoic acid, 9,13-di-cis-retinoic acid, and 14-hydroxy-4,14-retro-retinol in human plasma after liver consumption.
Identification of 9,13-dicis-retinoic acid as a major plasma metabolite of 9-cis-retinoic acid and limited transfer of 9-cis-retinoic acid and 9,13-dicis-retinoic acid to the mouse and rat embryos.
- G. Tzimas, J. Sass, W. Wittfoht, M. Elmazar, K. Ehlers, H. Nau
- BiologyDrug metabolism and disposition: the biological…
- 1 November 1994
Plasma levels of 9-cis-RA reached their maximum within 40-60 min and then declined in a monoexponential manner with an apparent half-life of 64 +/- 32 min, and an additional RA isomer in mouse plasma was shown to be an additionalRA isomer whose concentrations weeesimilarly high as those of9-c is-RA.
Valproate (VPA) Metabolites in Various Clinical Conditions of Probable VPA‐Associated Hepatotoxicity
Summary: Of a cohort of 470 epileptic patients in whom valproate (VPA) serum metabolites had been measured, 170 subjects without symptoms or signs of hepatic side effects were chosen as a reference…
Valproate Metabolites in Serum and Urine During Antiepileptic Therapy in Children with Infantile Spasms: Abnormal Metabolite Pattern Associated with Reversible Hepatotoxicity
The present study shows that initial stages of hepatotoxicity reactions to VPA may be accompanied by characteristic changes in VPA metabolism; early detection of such abnormal metabolite patterns might decrease the risk of severe hepatic injury.
Effects of methyltestosterone on reproduction in the Japanese quail (Coturnix coturnix japonica).
Plasma pharmacokinetics and metabolism of 13-cis- and all-trans-retinoic acid in the cynomolgus monkey and the identification of 13-cis- and all-trans-retinoyl-beta-glucuronides. A comparison to one…
The elimination of all-trans-RA in monkey was faster than that of 13-cis-RA and tended to increase with repeated dosing, and the AUCs were proportional to the dose administered, although low levels of isomerization products were observed.
Characterization of oxidized and glucuronidated metabolites of retinol in monkey plasma by thermospray liquid chromatography/mass spectrometry.
- C. Eckhoff, W. Wittfoht, H. Nau, W. Slikker
- Biology, ChemistryBiomedical & environmental mass spectrometry
- 1 July 1990
A major metabolic pathway of high-dose vitamin A in the non-human primate is apparently the oxidation of the primary alcohol group of retinol resulting in the formation of all-trans-retinoic acid.