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NALP1 Influences Susceptibility to Human Congenital Toxoplasmosis, Proinflammatory Cytokine Response, and Fate of Toxoplasma gondii-Infected Monocytic Cells
TLDR
It is suggested that the NALP1 inflammasome is critical for mediating innate immune responses to T. gondii infection and pathogenesis, the first report, to the authors' knowledge, on the crucial role of this protein in the pathogenesis of T. Gondii infections in humans. Expand
Development and application of a quantitative real-time PCR for the diagnosis of Surra in water buffaloes.
TLDR
Data indicate that real-time PCR for the estimation of putative parasitemia levels is a quantitatively and objectively applicable technique for clinical diagnosis of Surra, and could help to understand disease stage and risk of transmission of T. evansi. Expand
Molecular detection of trypanosomes in cattle in South America and genetic diversity of Trypanosoma evansi based on expression-site-associated gene 6.
TLDR
The results obtained in this study suggest that T. evansi isolates from South America are more diverse than the Asian isolate, and 20 novel variants of ESAG6 genes which could be categorized into three new clades among the various isolates. Expand
P2X7 Receptor-Mediated Killing of an Intracellular Parasite, Toxoplasma gondii, by Human and Murine Macrophages
TLDR
It is shown that macrophages from people with the 1513C loss-of-function P2X7R single nucleotide polymorphism are less effective in killing intracellular Toxoplasma gondii after exposure to ATP compared with macrophage fromPeople with the1513A wild-type allele. Expand
Disruption of the Plasmodium falciparum PfPMT Gene Results in a Complete Loss of Phosphatidylcholine Biosynthesis via the Serine-Decarboxylase-Phosphoethanolamine-Methyltransferase Pathway and Severe
TLDR
Genetic evidence is provided that knock-out of the PfPMT gene encoding the phosphoethanolamine methyltransferase enzyme completely abrogates the biosynthesis of phosphatidylcholine via the SDPM pathway. Expand
Expression of alternative oxidase inhibits programmed cell death-like phenomenon in bloodstream form of Trypanosoma brucei rhodesiense.
TLDR
Under high-density axenic culture conditions, bloodstream form of T. b. Expand
The plasma membrane permease PfNT1 is essential for purine salvage in the human malaria parasite Plasmodium falciparum.
TLDR
Transgenic parasites lacking the PPM transporter PfNT1 are auxotrophic for hypoxanthine, inosine, and adenosine under physiological conditions and are viable only if these normally essential nutrients are provided at excess concentrations. Expand
Identification of T. gondii epitopes, adjuvants, and host genetic factors that influence protection of mice and humans.
TLDR
Since peptide repertoire presented by MHC class I molecules to CD8(+) T cells is shaped by endoplasmic reticulum-associated aminopeptidase (ERAAP), polymorphisms in the human ERAAP gene ERAP1 were studied and associate with susceptibility to human congenital toxoplasmosis (p<0.05). Expand
Localization of the Phosphoethanolamine Methyltransferase of the Human Malaria Parasite Plasmodium falciparum to the Golgi Apparatus*
TLDR
It is shown that the level of Pfpmt protein in the infected erythrocyte is regulated in a stage-specific fashion, with high levels detected during the trophozoite stage at the peak of parasite membrane biogenesis. Expand
A Stem-Cell-Derived Platform Enables Complete Cryptosporidium Development In Vitro and Genetic Tractability
TLDR
A platform for complete life cycle development and long-term growth of C. parvum in vitro using “air-liquid interface” (ALI) cultures derived from intestinal epithelial stem cells is described. Expand
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