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A new look at the biogenesis of glycogen
The production of active glycogenin primer in the cell has the potential to be the overall rate‐limiting process in glycogen formation, capable of overriding the better understood hormonally controlled mechanisms of protein phosphorylation/dephosphorylation that regulate the activities of glycogen synthase and Phosphorylase. Expand
Proglycogen: A low‐molecular‐weight form of muscle glycogen
It is reported that muscle contains a trichloroacetic acid‐precipitable component that can be glucosylated by an endogenous enzyme acting on UDPglucose that is a glycogen‐like molecule constituting about 15% or total glycogen. Expand
Glycogen synthesis in the astrocyte: from glycogenin to proglycogen to glycogen
The astrocyte of the newborn rat brain has proven to be a versatile system in which to study glycogen biogenesis and the discovery of a low‐molecular‐weight form of glycogen, proglycogen, is taken. Expand
β‐Glucosylarginine: a new glucose‐protein bond in a self‐glucosylating protein from sweet corn
There is no homology with the amino acid sequence of the autocatalytic glycogen primer, glycogenin, nor in respect of the nature of the union between the autOCatalytically added glucose and the protein, which, in the case of the corn protein, is a novel glucose‐protein bond. Expand
A self‐glucosylating protein is the primer for rabbit muscle glycogen biosynthesis
The putative role of SGP in glycogen synthesis is confirmed by the fact that glucosylated SGP acts as a primer for glycogen synthase and branching enzyme to form high‐molecular‐weight material, which implies that SGP already carries an existing maltosaccharide chain or chains to which the glucose is added, rather than glucose being added directly to protein. Expand
A revision of the Meyer‐Bernfeld model of glycogen and amylopectin
The regularly rebranched structure originally proposed by Meyer and Bernfeld was the only one of the then existing proposals that could fit the results of exploration of glycogen and amylopectin with debranching enzymes, and the structure shown in fig. 1 has been generally accepted. Expand
Glycogen contains phosphodiester groups that can be introduced by UDPglucose:glycogen glucose 1‐phosphotransferase
A novel enzyme activity has been found in muscle that can account for the presence of the phosphodiester in glycogen, a UDPglucose:glycogen glucose 1 ‐phosphotransferase that positions glucose 1‐phosphate on C‐6 of glucose residues in glycogens, forming a diester. Expand