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Human papillomavirus and survival of patients with oropharyngeal cancer.
Tumor HPV status is a strong and independent prognostic factor for survival among patients with oropharyngeal cancer and the risk of death significantly increased with each additional pack-year of tobacco smoking.
Evidence for a causal association between human papillomavirus and a subset of head and neck cancers.
- M. Gillison, W. Koch, D. Sidransky
- Medicine, BiologyJournal of the National Cancer Institute
- 3 May 2000
It is suggested that HPV-positive oropharyngeal cancers comprise a distinct molecular, clinical, and pathologic disease entity that is likely causally associated with HPV infection and that has a markedly improved prognosis.
Case-control study of human papillomavirus and oropharyngeal cancer.
Oropharyngeal cancer was significantly associated with oral HPV type 16 (HPV-16) infection, and the degree of association increased with the number of vaginal-sex and oral-sex partners, among subjects with or without the established risk factors of tobacco and alcohol use.
Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1
To explore the genetic origins of head and neck squamous cell carcinoma, whole-exome sequencing and gene copy number analyses were used to study 32 primary tumors and identified mutations in FBXW7 and NotCH1, suggesting that NOTCH1 may function as a tumor suppressor gene rather than an oncogene in this tumor type.
Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial.
For patients with HNSCC of the oropharynx, tumor HPV status is strongly associated with therapeutic response and survival and, after adjustment for age, tumor stage, and ECOG performance status, lower risks of progression and death are found.
HPV-associated head and neck cancer: a virus-related cancer epidemic.
Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers.
HPV-16-positive HNSCCs and HPV- 16-negative H NSCCs have different risk factor profiles, indicating that they should be considered to be distinct cancers.
TP53 mutations and survival in squamous-cell carcinoma of the head and neck.
Disruptive TP53 mutations in tumor DNA are associated with reduced survival after surgical treatment of squamous-cell carcinoma of the head and neck.
BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer.
- M. Xing, W. Westra, P. Ladenson
- Medicine, BiologyThe Journal of clinical endocrinology and…
- 1 December 2005
In patients with PTC, BRAF mutation is associated with poorer clinicopathological outcomes and independently predicts recurrence, and may be a useful molecular marker to assist in risk stratification for patients withPTC.