W. Wescoe

Publications47
h-index10
Citations648
Highly Influential Citations10
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The Reticular Formation
TLDR
Research into the nature and function of the reticular formation of the brain stem rapidly gained momentum, and continues apace, and it is becoming increasingly clear that the concept of areticular formation as a single entity is wrong.
THE PHARMACOLOGY OF FLAXEDIL, WITH OBSERVATIONS ON CERTAIN ANALOGS
  • W. Riker, W. Wescoe
  • Chemistry, Medicine
    Annals of the New York Academy of Sciences
  • 1 October 1951
TLDR
The present report is concerned with the pharmacologic properties of Flaxedil, particularly as they compare with those of d-tubocurarine, which have had a considerable preliminary clinical trial in the practice of anesthesiology.
Regeneration rates of serum cholinesterase in normal individuals and in patients with liver damage.
  • W. Wescoe, C. Hunt
  • Chemistry, Medicine
    The American journal of physiology
  • 1 June 1947
The influence of atropine and scopolamine on the central effects of DFP.
TLDR
Data indicate that atropine prevents or annuls the central actions of ACh, and the action of DFP could be prevented or abolished by the intravenous administration ofAtropine or scopolamine.
THE PHARMACOLOGY OF ANTI‐CURARE AGENTS
  • W. Wescoe, W. Riker
  • Chemistry, Medicine
    Annals of the New York Academy of Sciences
  • 1 October 1951
TLDR
The working hypothesis was formulated that neostigmine probably possessed, in addition to its anti-cholinesterase properties, the property of acting directly on acetylcholine-sensitive receptors in skeletal muscle, and the potent anti-curare action of this compound suggested its use in clinical anesthesiology.
On the mechanism of the convulsant action of strychnine; the lack of atropine antagonism.
  • W. Wescoe, R. E. Green
  • Chemistry, Medicine
    The Journal of pharmacology and experimental…
  • 1 September 1948
TLDR
The facts indicate that it is unlikely that strychnine action upon the spinal cord is referable to its anti-cholinesterase properties, and it is well sustained unless the neuraxis is intact.
The direct action of prostigmine on skeletal muscle; its relationship to the choline esters.
  • W. Riker, W. Wescoe
  • Chemistry, Medicine
    The Journal of pharmacology and experimental…
  • 1 September 1946
TLDR
It is concluded that the action of prostigmine is primarily a direct one and differs from that of a primary anti-esterase (DFP), and it is suggested that prostIGmine be classified pharmacologically with the choline esters.
STUDIES ON THE INTER-RELATIONSHIP OFCERTAIN CHOLINERGIC COMPOUNDS I. The Pharmacology of 3-Acetoxy PhenyltrimethylammoniumMethylsulfate
1. 3-Acetoxy phenyltrimethylammonium methylsulfate, Nu 2017, is astructural intermediate to acetylcholine and neostigmine. Its pharmacologic effects encompass both muscarinic and nicotinic properties…
Effect of folic acid and liver extract on serum and red cell cholinesterase activity.
The relationship between cholinesterase inhibition and function in a neuroeffector system.
  • W. Riker, W. Wescoe
  • Chemistry, Medicine
    The Journal of pharmacology and experimental…
  • 1 April 1949
TLDR
The relationship between the inhibition of the cholinesterase (ChE) activity of the submaxillary gland and its physiologic responses is reported and the physiologic and pharmacologic inter-relationships affecting chemical mediation at neuro-effector junctions are discussed.
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