The Reticular Formation
- W. Wescoe
- 12 May 1962
Research into the nature and function of the reticular formation of the brain stem rapidly gained momentum, and continues apace, and it is becoming increasingly clear that the concept of areticular formation as a single entity is wrong.
THE PHARMACOLOGY OF FLAXEDIL, WITH OBSERVATIONS ON CERTAIN ANALOGS
The present report is concerned with the pharmacologic properties of Flaxedil, particularly as they compare with those of d-tubocurarine, which have had a considerable preliminary clinical trial in the practice of anesthesiology.
Regeneration rates of serum cholinesterase in normal individuals and in patients with liver damage.
The influence of atropine and scopolamine on the central effects of DFP.
Data indicate that atropine prevents or annuls the central actions of ACh, and the action of DFP could be prevented or abolished by the intravenous administration ofAtropine or scopolamine.
THE PHARMACOLOGY OF ANTI‐CURARE AGENTS
The working hypothesis was formulated that neostigmine probably possessed, in addition to its anti-cholinesterase properties, the property of acting directly on acetylcholine-sensitive receptors in skeletal muscle, and the potent anti-curare action of this compound suggested its use in clinical anesthesiology.
On the mechanism of the convulsant action of strychnine; the lack of atropine antagonism.
The facts indicate that it is unlikely that strychnine action upon the spinal cord is referable to its anti-cholinesterase properties, and it is well sustained unless the neuraxis is intact.
The direct action of prostigmine on skeletal muscle; its relationship to the choline esters.
It is concluded that the action of prostigmine is primarily a direct one and differs from that of a primary anti-esterase (DFP), and it is suggested that prostIGmine be classified pharmacologically with the choline esters.
STUDIES ON THE INTER-RELATIONSHIP OFCERTAIN CHOLINERGIC COMPOUNDS I. The Pharmacology of 3-Acetoxy PhenyltrimethylammoniumMethylsulfate
A mutual antagonism can be demonstrated between Nu 2017 and d-tubocurarine in the intact animal, which implies that untoward effects from excessive amounts of Nu 2017 are likely in the presence of curare, and the safety of Nu 2018 as anantidote to curare is enhanced by its rapid elimination.
Effect of folic acid and liver extract on serum and red cell cholinesterase activity.
The relationship between cholinesterase inhibition and function in a neuroeffector system.
The relationship between the inhibition of the cholinesterase (ChE) activity of the submaxillary gland and its physiologic responses is reported and the physiologic and pharmacologic inter-relationships affecting chemical mediation at neuro-effector junctions are discussed.