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Population genetic analysis and sub-structuring of Theileria parva in Uganda.
TLDR
Analysis of linkage disequilibrium between pairs of loci provides evidence that the population in Lira district had an epidemic structure and Genetic distances and Wrights fixation index (F(ST)) indicate that there is evidence for geographical sub-structuring between the Lira and the Kayunga populations. Expand
Genome of the Host-Cell Transforming Parasite Theileria annulata Compared with T. parva
TLDR
The genome of T. annulata is sequenced and the analysis reveals unequally expanded gene families and species-specific genes, and divergent families of putative secreted polypeptides that may reduce immune recognition. Expand
Diversity in parasitic nematode genomes: the microRNAs of Brugia pahangi and Haemonchus contortus are largely novel
TLDR
The in-depth comparative analysis of nematode miRNAs reveals the high level of divergence across species and identifies novel sequences potentially involved in development, and provides a detailed foundation for further study of the evolution and function of miRNAAs within nematodes and for identifying potential targets for intervention. Expand
The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host–parasite interaction
TLDR
VESA2 proteins are abundant and previously unrecognized elements of Babesia biology, with evolutionary dynamics consistently different to those of VESA1, suggesting that their functions are distinct. Expand
Whole-Genome Sequencing of Theileria parva Strains Provides Insight into Parasite Migration and Diversification in the African Continent
TLDR
The phylogeny of T. parva strains is elucidated based on genome-wide SNPs analysis with prediction of possible past recombination events, providing insight into the migration, diversification, and evolution of this parasite species in the African continent. Expand
Molecular approaches to diversity of populations of apicomplexan parasites.
TLDR
This review discusses the current understanding in 'Biodiversity and Population Genetics' of the major apicomplexan parasites, namely the Eimeria spp, Cryptosporidium spp. Expand
Alteration of host cell phenotype by Theileria annulata and Theileria parva: mining for manipulators in the parasite genomes.
TLDR
Current knowledge of the mechanisms used by Theileria parasites to transform the host cell is summarized, and recent work that has mined the Theilaria genomes to identify candidate manipulators of host cell phenotype is highlighted. Expand
Two Theileria parva CD8 T Cell Antigen Genes Are More Variable in Buffalo than Cattle Parasites, but Differ in Pattern of Sequence Diversity
TLDR
The results indicate that T.Parva parasites maintained in cattle represent a subset of the overall T. parva population, which has become adapted for tick transmission between cattle. Expand
Genetic exchange and sub-structuring in Theileria annulata populations.
TLDR
Population genetic analysis revealed a high level of genotypic diversity both between and within countries, as measured by the number of distinct multilocus genotypes, and whether genetic exchange occurs at random and the populations are panmictic was investigated. Expand
The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes
TLDR
It is shown that substantial quantities of trypanosomes exist within the skin following experimental infection, which can be transmitted to the tsetse vector, even in the absence of detectable parasitaemia. Expand
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