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Apelin, a new enteric peptide: localization in the gastrointestinal tract, ontogeny, and stimulation of gastric cell proliferation and of cholecystokinin secretion.
Apelin is a recently discovered peptide that is the endogenous ligand for the APJ receptor. The aim of this study was to characterize apelin expression (mRNA levels) in the rat gastrointestinal tract… Expand
Induction of oocyte-like cells from mouse embryonic stem cells by co-culture with ovarian granulosa cells.
- Tingting Qing, Y. Shi, +5 authors H. Deng
- Biology, Medicine
- Differentiation; research in biological diversity
- 1 December 2007
In vitro derivation of oocytes from embryonic stem (ES) cells has the potential to be an important tool for studying oogenesis as well as advancing the field of therapeutic cloning by providing an… Expand
SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis.
To determine the importance of suppressor of cytokine signaling-3 (SOCS3) in the regulation of hematopoietic growth factor signaling generally, and of G-CSF-induced cellular responses specifically,… Expand
Melatonin reduces memory changes and neural oxidative damage in mice treated with D‐galactose
To investigate the role of melatonin in D‐galactose‐induced amnesic mice, the avoidance/escape and water maze tests were performed to evaluate their learning and memory function. Spectrophotometry… Expand
Primordial Germ Cell Specification from Embryonic Stem Cells
Background Primordial germ cell (PGC) specification is the first crucial step in germ line development. However, owing to significant challenges regarding the in vivo system, such as the complex… Expand
Regulation of T Cell Priming by Lymphoid Stroma
The priming of immune T cells by their interaction with dendritic cells (DCs) in lymph nodes (LN), one of the early events in productive adaptive immune responses, occurs on a scaffold of lymphoid… Expand
Sustained activation of nuclear factor-&kgr;B by reactive oxygen species is involved in the pathogenesis of stress-induced gastric damage in rats
Objective:Stress ulceration is a common complication in critically ill patients, but the mechanisms involved are poorly understood. In this study we investigated the temporal activation of the… Expand
Small molecule antagonists of Tcf4/β‐catenin complex inhibit the growth of HCC cells in vitro and in vivo
Hepatocellular carcinoma (HCC) is the 5th most common cancer worldwide. It is intrinsically resistant toward standard chemotherapy, making it imperative to develop novel selective chemotherapeutic… Expand
Blocking A2B Adenosine Receptor Alleviates Pathogenesis of Experimental Autoimmune Encephalomyelitis via Inhibition of IL-6 Production and Th17 Differentiation
Adenosine is a key endogenous signaling molecule that regulates immune responses. A2B adenosine receptor (AR) is a relatively low-affinity receptor for adenosine, and the activation of A2BAR is… Expand
Effects and mechanisms of Paeoniflorin, a bioactive glucoside from paeony root, on adjuvant arthritis in rats
Abstract.Objective and design:Paeoniae alba Radix has been recognized as a valuable herb in the treatment of rheumatoid arthritis (RA) in traditional Chinese medicine. The purpose of this study was… Expand