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The cardiovascular effects of mivacurium chloride (BW B1090U) in patients receiving nitrous oxide-opiate-barbiturate anesthesia.
The dose-effect relationship of mivacurium chloride on arterial blood pressure, heart rate, and plasma histamine was determined in 97 consenting ASA physical status I-II patients receiving nitrousExpand
Comparative Pharmacology of Cisatracurium (51W89), Atracurium, and Five Isomers in Cats
Background Atracurium has four chiral centers and the marketed product is a mixture of ten optical and geometric isomers. Six of the isomers were prepared and evaluated for neuromuscular blockingExpand
Measurement of cyclic 3',5'-denosine monophosphate by the activation of skeletal muscle protein kinase.
Abstract Cyclic 3',5'-adenosine monophosphate can be measured directly in crude tissue extracts by its stimulation of the rate of phosphorylation of casein catalyzed by skeletal muscle proteinExpand
Concerning the distribution of endogenous norepinephrine in the adventitial and media-intimal layers of the rabbit aorta and the capacity of these layers to bind tritiated norepinephrine.
Approximately 75% of the endogenous norepinephrine content of rabbit thoracic aorta resides in the adventitia; the remainder resides in the media-intimal layers. Approximately 75 to 90% of theExpand
Pharmacological Properties of 403U76, a New Chemical Class of 5‐Hydroxytryptamine‐ and Noradrenaline‐reuptake Inhibitor
403U76 (5‐chloro‐[[2‐[(dimethylamino)methyl]phenyl]thio]benzene‐methanol hydrochloride) is a potent, competitive, inhibitor of 5‐hydroxytryptamine (5‐HT) and noradenaline reuptake into rat brainExpand
Preclinical Pharmacology of GW280430A (AV430A) in the Rhesus Monkey and in the Cat: A Comparison with Mivacurium
BackgroundNo replacement for succinylcholine is yet available. GW280430A (AV430A) is a representative of a new class of nondepolarizing neuromuscular blocking drugs called asymmetric mixed-oniumExpand
Preclinical Pharmacology in the Rhesus Monkey of CW 1759-50, a New Ultra-short Acting Nondepolarizing Neuromuscular Blocking Agent, Degraded and Antagonized by L-Cysteine
What We Already Know about This Topic Gantacurium is an ultra-short acting nondepolarizing neuromuscular blocking agent in the monkey and in man that is degraded nonenzymatically by adduction ofExpand
Clinical Pharmacology of Doxacurium Chloride A New Long‐acting Nondepolarlzlng Muscle Relaxant
Doxacurium chloride (BW A938U) is a bis-quaternary benzyl-isoquinolinium diester nondepolarizing neuromuscular blocking compound that is minimally hydrolyzed by human plasma cholinesterase. TheExpand
Blockade of biochemical and physiological responses of cardiac muscle to norepinephrine by N-tert.-butylmethoxamine (butoxamine).
Methoxamine congeners have been described as beta 2 adrenergic blocking agents with little effect on cardiac adrenergic responses and also as having the capacity to block the formation of cardiacExpand
Some factors determining the response of rabbit aortic strips to dl-norepinephrine-7-H3 hydrochloride and the influence of cocaine, guanethidine and methylphenidate on these factors.
Some factors determining the contractile response of rabbit aortic strips to norepinephrine have been studied. Norepinephrine is taken up and bound as increasing, linear functions of time fromExpand