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Uric acid as a risk factor for cardiovascular disease.
TLDR
It has been difficult to identify the specific role of elevated serum uric acid because of its association with established cardiovascular risk factors such as hypertension, diabetes mellitus, hyperlipidaemia and obesity, but increased understanding of the mechanisms underlying these associations may allow a clearer interpretation of the importance of elevated urate‐lowering treatment. Expand
Cardiovascular Effects of Acute Oxygen Administration in Healthy Adults
TLDR
It is indicated that oxygen administration causes acute effects on cardiovascular function, which might be important in the context of acute illness. Expand
Risk factors and mechanisms of anaphylactoid reactions to acetylcysteine in acetaminophen overdose
TLDR
Acetaminophen is protective against adverse effects of NAC, and mechanisms by which acetaminophen might lessen histamine release require further attention. Expand
Lower incidence of anaphylactoid reactions to N-acetylcysteine in patients with high acetaminophen concentrations after overdose
TLDR
High serum acetaminophen concentrations were associated with fewer anaphylactoid reactions, suggesting that these might in some way be protective, and the biological basis needs further exploration to allow a better understanding of the mechanisms responsible for adverse reactions to NAC treatment. Expand
Uric acid reduces exercise-induced oxidative stress in healthy adults.
TLDR
High UA concentrations are associated with increased serum antioxidant capacity and reduced oxidative stress during acute physical exercise in healthy subjects, indicating that the antioxidant properties of UA are of biological importance in vivo. Expand
Earlier recognition of nephrotoxicity using novel biomarkers of acute kidney injury
TLDR
Novel biomarkers appear capable of offering a more sensitive means of detecting acute kidney injury than existing approaches, and comparatively few clinical data exist to support their validity in routine practice. Expand
Evaluation of a QT nomogram for risk assessment after antidepressant overdose.
TLDR
The QT nomogram was associated with a lower false positive rate than widely accepted QT(c) criteria, and allowed detection of different effects of individual drugs. Expand
Patterns of antiepileptic drug overdose differ between men and women: admissions to the Edinburgh Poisons Unit, 2000-2007.
TLDR
Patients that ingested antiepileptic drugs required more intensive medical and psychiatric intervention compared to ingestion of other agents and further work is required to establish whether this discrepancy may be explained by gender-based prescribing practices. Expand
Uric Acid Restores Endothelial Function in Patients With Type 1 Diabetes and Regular Smokers
TLDR
Uric acid administration improved endothelial function in the forearm vascular bed of patients with type 1 diabetes and smokers, suggesting that high uric acid concentrations in vivo might serve a protective role in these and other conditions associated with increased cardiovascular risk. Expand
Methoxetamine associated reversible cerebellar toxicity: Three cases with analytical confirmation
TLDR
Methoxetamine may cause rapid onset of neurological impairment, characterised by acute cerebellar toxicity, which should alert clinicians to the possibility of methoxetamines exposure. Expand
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