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Captopril inhibits angiogenesis and slows the growth of experimental tumors in rats.
TLDR
This widely used drug is defined as a new inhibitor of neovascularization and the possibility that patients on long term captopril therapy may derive unexpected benefits from its antiangiogenic activities is raised. Expand
Effect of an angiotensin II receptor blocker and two angiotensin converting enzyme inhibitors on transforming growth factor-beta (TGF-beta) and alpha-actomyosin (alpha SMA), important mediators of
TLDR
The finding that ACE inhibitors or ANG II receptor blockers protect the lungs from radiation induced pneumonitis and fibrosis reaffirms the role that ANG II plays in this inflammatory process and suggests an additional indication of treatment of this condition, thus opening a new potential pharmacologic use of these drugs. Expand
Control of radiation-induced pneumopathy and lung fibrosis by angiotensin-converting enzyme inhibitors and an angiotensin II type 1 receptor blocker.
TLDR
ACE inhibitors and one AII type 1 receptor blocker were effective in protecting lungs from radiation-induced pneumonitis and the development of lung fibrosis in two models of rat radiation injury. Expand
KGF facilitates repair of radiation-induced DNA damage in alveolar epithelial cells.
TLDR
KGF increases DNA repair capacity in irradiated pulmonary epithelial cells, an effect mediated at least in part by DNA polymerases-alpha, -delta, and -epsilon, which may be one mechanism by which KGF is able to ameliorate oxidant-mediated alveolar epithelial injury. Expand
Effect of an angiotensin II receptor blocker and two angiotensin converting enzyme inhibitors on transforming growth factor-β (TGF-β) and α-actomyosin (α SMA), important mediators of
TLDR
The finding that ACE inhibitors or ANG II receptor blockers protect the lungs from radiation induced pneumonitis and fibrosis reaffirms the role that ANG II plays in this inflammatory process and suggests an additional indication of treatment of this condition, thus opening a new potential pharmacologic use of these drugs. Expand
Survival of penicillamine-treated mice following whole-body irradiation.
D-Penicillamine (P,P3-dimethylcysteine) protected male mice against whole-body radiation lethality when the drug was injected (ip) before but not after irradiation. The LD50/30 of control mice wasExpand
Whole-thorax radiation lethality in penicillamine-treated mice.
TLDR
While penicillamine did not reduce the incidence of early (<6 months) lung deaths, drug-treated mice weighed significantly more than their untreated counterparts during that time and significantly reduces mortality resulting from radiation-induced pulmonary fibrosis in mice irradiated to the whole thorax. Expand
Radiation injury in rat lung. I. Prostacyclin (PGI2) production, arterial perfusion, and ultrastructure.
Pulmonary prostacyclin (PGI2) production, arterial perfusion, and ultrastructure were correlated in rats sacrificed from 1 day to 6 months after a single exposure of 25 Gy of gamma rays to the rightExpand
Captopril preserves function and ultrastructure in experimental radiation nephropathy.
TLDR
It is concluded that captopril exerts significant functional and structural protection against renal radiation injury and notable reduction in radiation-induced fibrosis incaptopril-treated animals in this model, as in experimental lung radiation injury. Expand
Captopril reduces collagen and mast cell accumulation in irradiated rat lung.
TLDR
These data are the first to demonstrate that the ACE inhibitor captopril might provide a novel intervention in the pathogenesis of radiation fibrosis. Expand
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