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New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals
- L. Zecca, C. Bellei, +15 authors F. Zucca
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 11 November 2008
Neuronal pigments of melanic type were identified in the putamen, cortex, cerebellum, and other major regions of human brain. These pigments consist of granules 30 nm in size, contained in organelles… Expand
Identification and quantification of dolichol and dolichoic acid in neuromelanin from substantia nigra of the human brains⃞ Published, JLR Papers in Press, April 19, 2007.
Neuromelanin (NM) isolated from the substantia nigra of the human brain is found to contain a series of dolichoic acids (dol-CA) containing 14–20 isoprene units. This is the first observation of… Expand
Neuromelanins in various regions of human brain are associated with native and oxidized isoprenoid lipids.
- W. Ward, F. Zucca, C. Bellei, L. Zecca, J. Simon
- Chemistry, Medicine
- Archives of biochemistry and biophysics
- 1 April 2009
Neuromelanin (NM) isolated from seven regions of the human brain is found to contain series of natural and oxidized isoprenoid lipids. Specifically, dolichols (dol) and dolichoic acids (dol-CA) with… Expand
Quantification of Naturally Occurring Pyrrole Acids in Melanosomes †
- W. Ward, Erin C Lamb, David M. Gooden, X. Chen, D. J. Burinsky, J. Simon
- Chemistry, Medicine
- Photochemistry and photobiology
- 1 May 2008
Three naturally occurring pyrrole acids were found in Sepia, human black hair, and bovine choroid and iris melanosomes using high‐performance liquid chromatography and mass… Expand
The differing embryonic origins of retinal and uveal (iris/ciliary body and choroid) melanosomes are mirrored by their phospholipid composition.
The phospholipids present in uveal (iris/ciliary body and choroid) and retinal bovine ocular melanosomes were identified using mass spectrometry. Similar phospholipid content is found for the two… Expand
Structural requirements of the human sodium-dependent bile acid transporter (hASBT): role of 3- and 7-OH moieties on binding and translocation of bile acids.
Bile acids (BAs) are the end products of cholesterol metabolism. One of the critical steps in their biosynthesis involves the isomerization of the 3β-hydroxyl (-OH) group on the cholestane ring to… Expand
SCY-641 - A Water-Soluble Cyclophilin Inhibitor for the Treatment of Dry Eye Disease
A06 Chdi-00340246, A Kynurenine Monooxygenase Inhibitor As Potential Therapeutic Agent For The Treatment Of Huntington’s Disease
- Leticia M. Toledo-Sherman, M. Prime, +21 authors C. Dominguez
- Journal of Neurology, Neurosurgery & Psychiatry
- 1 September 2014
Deregulation of the Kynurenine Pathway, has been causally implicated in the pathophysiology of HD. Metabolites of this pathway have been shown to be neurotoxic (3-Hydroxy kynurenine (3-HK) and… Expand