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Cap binding and immune evasion revealed by Lassa nucleoprotein structure
Lassa virus, the causative agent of Lassa fever, causes thousands of deaths annually and is a biological threat agent, for which there is no vaccine and limited therapy. The nucleoprotein (NP) ofExpand
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Robust Multiple Kernel K-means Using L21-Norm
TLDR
We propose a novel robust multiple kernel k-means algorithm that simultaneously finds the best clustering label, the cluster membership and the optimal combination of multiple kernels. Expand
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Determination of the spread parameter in the Gaussian kernel for classification and regression
TLDR
We show that the spread parameter σ in the Gaussian kernel is essential to generalization performance of SVMs. Expand
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Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression*
Background: Arenaviral nucleoproteins play a critical role in innate immune suppression. Results: Structures of Lassa nucleoprotein in complex with triphosphate dsRNA and Tacaribe virus nucleoproteinExpand
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Oxidized low-density lipoprotein induces secretion of interleukin-1β by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation.
Oxidized low-density lipoprotein (ox-LDL) is a critical mediator of atherogenesis. Macrophage uptake of ox-LDL and their subsequent development into foam cells is the principal event inExpand
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An active learning-based SVM multi-class classification model
TLDR
This paper presents a multi-class classification model that is based on active learning and support vector machines (MC_SVMA), which can be used to address unlabeled data. Expand
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Serum HOTAIR as a novel diagnostic biomarker for esophageal squamous cell carcinoma
BackgroundEarly diagnosis of esophageal squamous cell carcinoma (ESCC) is an important issue to improve the prognosis. HOX transcript antisense RNA (HOTAIR), a long noncoding RNA (lncRNA) expressedExpand
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A heuristic training for support vector regression
TLDR
A heuristic method for accelerating support vector machine (SVM) training based on a measurement of similarity among samples is presented in this paper. Expand
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MicroRNA-505 identified from patients with essential hypertension impairs endothelial cell migration and tube formation.
OBJECTIVES MicroRNAs are potent regulators of gene expression and may serve as disease markers. This study aimed to identify the plasma microRNA signature in hypertensive patients, which may helpExpand
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System Design for Big Data Application in Emotion-Aware Healthcare
TLDR
We design a system for big data application in emotion-aware healthcare (BDAEH), which pays attention to both the logic reasoning and the emotion computing, which is expected to validly improve the healthcare services by considering the emotion factor. Expand
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