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Structure of a kinesin–tubulin complex and implications for kinesin motility
The typical function of kinesins is to transport cargo along microtubules. Binding of ATP to microtubule-attached motile kinesins leads to cargo displacement. To better understand the nature of theExpand
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Modified Vaccinia Virus Ankara Triggers Type I IFN Production in Murine Conventional Dendritic Cells via a cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway
Modified vaccinia virus Ankara (MVA) is an attenuated poxvirus that has been engineered as a vaccine against infectious agents and cancers. Our goal is to understand how MVA modulates innate immunityExpand
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Feeding Preference and Survival of Young Worker Honey Bees (Hymenoptera: Apidae) Fed Rape, Sesame, and Sunflower Pollen
Young worker honey bees, Apis mellifera L., exhibited differences in feeding preferences and survival when fed pollen of rape, Brassica napus L., sesame, Sesamum indicum L., and sunflower, HelianthusExpand
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Spin-Valve Effect in NiFe/MoS2/NiFe Junctions.
Two-dimensional (2D) layered transition metal dichalcogenides (TMDs) have been recently proposed as appealing candidate materials for spintronic applications owing to their distinctive atomic crystalExpand
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Innate Immune Response of Human Plasmacytoid Dendritic Cells to Poxvirus Infection Is Subverted by Vaccinia E3 via Its Z-DNA/RNA Binding Domain
Plasmacytoid dendritic cells (pDCs) play important roles in antiviral innate immunity by producing type I interferon (IFN). In this study, we assess the immune responses of primary human pDCs to twoExpand
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New Insights into the Coupling between Microtubule Depolymerization and ATP Hydrolysis by Kinesin-13 Protein Kif2C*
Background: It is unclear whether microtubule depolymerization by kinesin-13s is coupled with the hydrolysis step of ATP turnover. Results: Mutation of the kinesin-13-specific KVD motif blocks ATPaseExpand
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Validation of the Pretreatment Neutrophil-Lymphocyte Ratio as a Predictor of Overall Survival in a Cohort of Patients With Pancreatic Ductal Adenocarcinoma
Objectives The circulating neutrophil-lymphocyte ratio (NLR) has been shown to be a prognostic factor for a variety of tumors. In this study, we evaluated the prognostic significance of NLR in aExpand
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Tunable Ambipolar Polarization-Sensitive Photodetectors Based on High-Anisotropy ReSe2 Nanosheets.
Atomically thin 2D-layered transition-metal dichalcogenides have been studied extensively in recent years because of their intriguing physical properties and promising applications in nanoelectronicExpand
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A novel xanthone dimer derivative with antibacterial activity isolated from the bark of Garcinia mangostana
Abstract A novel xanthone dimer derivative, garmoxanthone (1), together with 10 known compounds (2–11), were isolated from bark of Garcinia mangostana. Their structures were established throughExpand
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Kif2C Minimal Functional Domain Has Unusual Nucleotide Binding Properties That Are Adapted to Microtubule Depolymerization*
Background: Kinesin-13 proteins, such as Kif2C, share a conserved motor domain with motile kinesins, but they depolymerize microtubules. Results: Kif2C is mostly ATP-bound, and Kif2C-ATP has a strongExpand
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