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- Publications
- Influence
Phase variation of a β‐1,3 galactosyltransferase involved in generation of the ganglioside GM1‐like lipo‐oligosaccharide of Campylobacter jejuni
- D. Linton, M. Gilbert, +5 authors B. Wren
- Biology, Medicine
- Molecular microbiology
- 1 August 2000
Ganglioside mimicry by Campylobacter jejuni lipo‐oligosaccharide (LOS) is thought to be a critical factor in the triggering of the Guillain–Barré and Miller–Fisher syndrome neuropathies after C.… Expand
Crystal structure of the retaining galactosyltransferase LgtC from Neisseria meningitidis in complex with donor and acceptor sugar analogs
- K. Persson, H. Ly, M. Dieckelmann, W. Wakarchuk, S. Withers, N. Strynadka
- Chemistry, Medicine
- Nature Structural Biology
- 2001
Many bacterial pathogens express lipooligosaccharides that mimic human cell surface glycoconjugates, enabling them to attach to host receptors and to evade the immune response. In Neisseria… Expand
The Genetic Bases for the Variation in the Lipo-oligosaccharide of the Mucosal Pathogen, Campylobacter jejuni
- M. Gilbert, M. Karwaski, +5 authors W. Wakarchuk
- Biology, Medicine
- The Journal of Biological Chemistry
- 4 January 2002
We have compared the lipo-oligosaccharide (LOS) biosynthesis loci from 11 Campylobacter jejunistrains expressing a total of 8 different ganglioside mimics in their LOS outer cores. Based on the… Expand
Biosynthesis of Ganglioside Mimics in Campylobacter jejuni OH4384
- M. Gilbert, J. Brisson, +5 authors W. Wakarchuk
- Biology, Medicine
- The Journal of Biological Chemistry
- 11 February 2000
We have applied two strategies for the cloning of four genes responsible for the biosynthesis of the GT1a ganglioside mimic in the lipooligosaccharide (LOS) of a bacterial pathogen,Campylobacter… Expand
Functional Characterization of Dehydratase/Aminotransferase Pairs from Helicobacter and Campylobacter
- Ian C. Schoenhofen, David J. Mcnally, +6 authors S. Logan
- Biology, Medicine
- Journal of Biological Chemistry
- 13 January 2006
Helicobacter pylori and Campylobacter jejuni have been shown to modify their flagellins with pseudaminic acid (Pse), via O-linkage, while C. jejuni also possesses a general protein glycosylation… Expand
Mutational and crystallographic analyses of the active site residues of the bacillus circulans xylanase
- W. Wakarchuk, R. Campbell, W. Sung, J. Davoodi, M. Yaguchi
- Chemistry, Medicine
- Protein science : a publication of the Protein…
- 1 March 1994
Using site‐directed mutagenesis we have investigated the catalytic residues in a xylanase from Bacillus circulans. Analysis of the mutants E78D and E172D indicated that mutations in these conserved… Expand
Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog
- C. P. C. Chiu, A. Watts, +5 authors N. Strynadka
- Biology, Medicine
- Nature Structural &Molecular Biology
- 2004
Sialic acid terminates oligosaccharide chains on mammalian and microbial cell surfaces, playing critical roles in recognition and adherence. The enzymes that transfer the sialic acid moiety from… Expand
The structures of the lipooligosaccharide and capsule polysaccharide of Campylobacter jejuni genome sequenced strain NCTC 11168.
- F. St. Michael, C. Szymanski, +6 authors M. A. Monteiro
- Biology, Medicine
- European journal of biochemistry
- 1 November 2002
Campylobacter jejuni infections are one of the leading causes of human gastroenteritis and are suspected of being a precursor to Guillain-Barré and Miller-Fisher syndromes. Recently, the complete… Expand
Analysis of Campylobacter jejuni capsular loci reveals multiple mechanisms for the generation of structural diversity and the ability to form complex heptoses
- A. V. Karlyshev, O. Champion, +14 authors C. Szymanski
- Biology, Medicine
- Molecular microbiology
- 27 October 2004
We recently demonstrated that Campylobacter jejuni produces a capsular polysaccharide (CPS) that is the major antigenic component of the classical Penner serotyping system distinguishing… Expand
Structural insight into mammalian sialyltransferases
- F. V. Rao, J. Rich, +8 authors N. Strynadka
- Biology, Medicine
- Nature Structural &Molecular Biology
- 1 November 2009
Sialic acid is the most abundant terminal monosaccharide on mammalian cell surface glycoconjugates. The crystal structures of a mammalian sialyltransferase, that of porcine ST3Gal-I, in the apo form… Expand