Peroxisome proliferator-activated receptors: nuclear control of metabolism.
This work has shown that direct expression of PPAR mRNAs in the absence of a specific carrier gene results in down-regulation in the activity of other PPARs, and these properties are consistent with those of a “spatially aggregating substance”.
Transcriptional regulation of metabolism.
This review reviews data on the transcriptional regulation of the intermediary metabolism, i.e., glucose, amino acid, lipid, and cholesterol metabolism and discusses how transcription factors integrate signals from various pathways to ensure homeostasis.
Roles of PPARs in health and disease
The latest developments in the PPAR field are presented, with particular emphasis on the physiological function ofPPARs during various nutritional states, and the possible role of PPARs in several chronic diseases.
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma.
It is shown that certain mono- and polyunsaturated fatty acids bind directly to PPARalpha and PPARgamma at physiological concentrations, and that the eicosanoids 8(S)-hydroxyeicosatetraenoic acid and 15-deoxy-Delta12,14-prostaglandin J2 can function as subtype-selective ligands for PPAR alpha and PPARS, respectively.
Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat.
This work presents the expression patterns of the PPAR subtypes in the adult rat, determined by in situ hybridization using specific probes for PPAR-alpha, -beta and -gamma, and by immunohistochemistry using a polyclonal antibody that recognizes the three rat PPar subtypes.
Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay.
The results suggest that PPARs, by their ability to interact with a number of structurally diverse compounds, have acquired unique ligand-binding properties among the superfamily of nuclear receptors that are compatible with their biological activity.
Characterization of the Fasting-induced Adipose Factor FIAF, a Novel Peroxisome Proliferator-activated Receptor Target Gene*
- S. Kersten, S. Mandard, W. Wahli
- Biology, Computer ScienceJournal of Biological Chemistry
- 15 September 2000
The data suggest that FIAF represents a novel endocrine signal involved in the regulation of metabolism, especially under fasting conditions, and is strongly up-regulated by fasting in white adipose tissue and liver.
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
Evidence that PPARs serve as physiological sensors of lipid levels is provided and a molecular mechanism whereby dietary fatty acids can modulate lipid homeostasis is suggested.
Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting.
- S. Kersten, J. Seydoux, J. Peters, F. Gonzalez, B. Desvergne, W. Wahli
- BiologyJournal of Clinical Investigation
It is shown that to accommodate the increased requirement for hepatic fatty acid oxidation, PPAR alpha mRNA is induced during fasting in wild-type mice, indicating that PPARalpha plays a pivotal role in the management of energy stores during fasting.