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Human insulin receptor substrate-2: gene organization and promoter characterization.
Insulin receptor substrate-2 (IRS-2) belongs to a family of cytoplasmic adaptor proteins, which link insulin, IGF-1, and cytokine receptor tyrosine kinases to signaling pathways regulatingExpand
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Increased carotid artery intima-media thickness as an indicator of the onset of atherosclerosis in patients with connective tissue systemic diseases.
BACKGROUND Systemic connective tissue diseases have an autoimmunological background. Atherosclerosis is the main cause of ischaemic heart disease in patients with these disorders, particularly inExpand
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[Thrombotic thrombocytopenic purpura with myocardial ischaemia: two case reports].
Thrombotic thrombocytopenic purpura (TTP) is mainly perceived by cardiologists as a rare complication of ticlopidine or clopidogrel treatment. However, this life-threatening disease is provoked notExpand
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Relationship between bleeding time, aspirin and the PlA1/A2 polymorphism of platelet glycoprotein IIIa
A single nucleotide T to C transition of the gene encoding glycoprotein IIIa leads to a common diallelic polymorphism Leu‐33→Pro (PLA1/A2). We studied the relationship between the PlA1/A2Expand
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Antithrombotic effects of aspirin based on PLA1/A2 glycoprotein IIIa polymorphism in patients with coronary artery disease.
OBJECTIVE The diallelic glycoprotein IIIa polymorphism P1A1/A2 was attributed to be an inherited risk factor for coronary events. Whether this polymorphism affects response to aspirin in patientsExpand
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The additive antiplatelet action of clopidogrel in patients with coronary artery disease treated with aspirin.
We searched for additional anti-platelet effects of clopidogrel in coronary artery disease (CAD) patients treated with aspirin. Response to clopidogrel was also stratified according to aspirinExpand
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Human insulin receptor substrate-2 (IRS-2) is a primary progesterone response gene.
Elevated cAMP has been shown to unmask agonist activity of antiprogestin/antiglucocorticoid RU486. In our search for cellular target genes induced through this cross-talk mechanism, we identifiedExpand
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Assessment of hemocompatibility of materials with arterial blood flow by platelet functional tests
Hemocompatibility test of medical materials aims to detect adverse interaction between artificial surface and blood, which can activate or destruct blood components. In arterial flow conditions, dueExpand
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Anti-thrombotic action of clopidogrel and P1(A1/A2) polymorphism of beta3 integrin in patients with coronary artery disease not being treated with aspirin.
Individual variability in response to clopidogrel is known but its mechanism is poorly understood. We examined the relationship between glycoprotein IIIa polymorphism P1(A1/A2) and anti-thromboticExpand
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[Plasmapheresis in intensive therapy unit].
Plasmapheresis or therapeutic plasma exchange is a procedure designed to deplete the body of blood plasma without blood cells. Whole blood is removed from the body, the plasma is separated from theExpand
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