• Publications
  • Influence
Cadmium-induced apoptosis in C6 glioma cells: Influence of oxidative stress
TLDR
It is shown that short time incubations with cadmium caused only slight or insignificant effects on the generation of reactive oxygen species, whereas incubation with this heavy metal for 24 h lead to a decrease in intracellular glutathione concentration and an increase in oxidative DNA-lesions. Expand
Low concentrations of flavonoids are protective in rat H4IIE cells whereas high concentrations cause DNA damage and apoptosis.
TLDR
The data suggest that cytoprotective concentrations of some flavonoids are lower by a factor of 5-10 than their DNA-damaging and proapoptotic concentrations. Expand
Cadmium-induced apoptosis in C6 glioma cells: Mediation by caspase 9-activation
TLDR
The mode of cadmium-induced cellular death was identified to involve apoptotic DNA fragmentation in three cell lines, i.e., in C6 glioma cells, E367 neuroblastoma cells and NIH3T3 fibroblasts, and an activation of caspase 9, a protease known to be activated in apoptotic processes following mitochondrial damage was found. Expand
Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation.
TLDR
Enniatins A1 and B1 and, to a lesser extent, enniatin B may possess anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. Expand
The Ginkgo biloba extract EGb761 reduces stress sensitivity, ROS accumulation and expression of catalase and glutathione S-transferase 4 in Caenorhabditis elegans.
TLDR
The results suggest that the beneficial impact of EGb791 on resistance to thermal stress and lifespan in C. elegans is at least partially due to its ability to relieve oxidative stress. Expand
Myricetin-Mediated Lifespan Extension in Caenorhabditis elegans Is Modulated by DAF-16
TLDR
Results strongly indicate that the pro-longevity effect of myricetin is dependent on DAF-16 and not on direct anti-oxidative effects of the flavonoid. Expand
Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin.
TLDR
It is suggested that the protective and life prolonging action of quercetin is not only due to its strong antioxidant capacity but may also be mediated by modulation of signalling pathways. Expand
Investigations of protective effects of the flavonoids quercetin and rutin on stress resistance in the model organism Caenorhabditis elegans.
TLDR
The results suggest that quercetin may act as an antioxidant as well as a modulator of cellular signalling processes to exert its protective properties. Expand
Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis elegans
TLDR
Both flavonoids increased the survival of C. elegans, reduced the intracellular ROS accumulation at lethal thermal stress, and diminished the extent of induced oxidative stress with kaempferol having a stronger impact. Expand
Caffeic Acid Phenethylester Increases Stress Resistance and Enhances Lifespan in Caenorhabditis elegans by Modulation of the Insulin-Like DAF-16 Signalling Pathway
TLDR
CAPE activates the insulin-like DAF-16, but not the SKN-1 signalling pathway in C. elegans and therefore enhances the stress resistance and lifespan of this organism and is taken into account for the investigation of the molecular mechanisms of the traditional use of propolis. Expand
...
1
2
3
4
5
...