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Analytical methods for the determination of sulindac and metabolites in plasma, urine, bile, and gastric fluid by liquid chromatography using ultraviolet detection.
A high-performance liquid chromatographic method using a linear elution gradient has been developed for the analysis of sulindac, sulindac sulfone, and sulindac sulfide in plasma, urine, bile, and
Optically pure (+)-nicotine from (+/-)-nicotine and biological comparisons with (-)-nicotine.
TLDR
Optically pure (+-nicotine has been obtained from (+/-)-nicotine using a combination of d-tartaric acid and di-p-toluoyl-l-tartsaric Acid, indicating substantial stereospecificity for nicotine receptors.
Studies on the disposition of phencyclidine in mice.
Nonisothermal kinetic studies III: rapid nonisothermal-isothermal method for stability prediction.
TLDR
A continuous nonisothermal-isothermal method for stability prediction was developed that yields all necessary parameters for prediction, including reaction order, which is applicable to acid-catalyzed hydrolysis of acetylcholine bromide and the inversion of sucrose.
Synthesis of 4,4-ditritio-(+)-nicotine: comparative binding and distribution studies with natural enantiomer.
TLDR
Although Ib is 10-30 times less potent than (-)-nicotine (Ia) in the CNS, its binding affinity for the crude mitochondrial or nuclear fraction of whole rat brain is only three times less than that of Ia, and distribution studies showed that the maximum brain levels of (-)-[3H] nicotine are nearly twice those of (+)-[ 3H]-nicotine following administration of a 2-micrograms/kg dose.
Enterohepatic circulation of sulindac and metabolites
TLDR
There is a correlation between data in man and those in five other species and the data established that, after sulindac, the contribution of enterohepatic circulation to conservation of the active pharmacophore is achieved predominantly at the level of inactive prodrug.
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