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High-performance liquid chromatographic determination of cilastatin in biological fluids.
Analytical method for the quantification of famotidine, an H2-receptor blocker, in plasma and urine.
A liquid chromatographic assay for phenylethanolamine N-methyltransferase.
Analytical methods for the determination of sulindac and metabolites in plasma, urine, bile, and gastric fluid by liquid chromatography using ultraviolet detection.
- D. Musson, W. Vincek, M. Constanzer, T. E. Detty
- Biology, MedicineJournal of pharmaceutical sciences
- 1 September 1984
A high-performance liquid chromatographic method using a linear elution gradient has been developed for the analysis of sulindac, sulindac sulfone, and sulindac sulfide in plasma, urine, bile, and…
Optically pure (+)-nicotine from (+/-)-nicotine and biological comparisons with (-)-nicotine.
Optically pure (+-nicotine has been obtained from (+/-)-nicotine using a combination of d-tartaric acid and di-p-toluoyl-l-tartsaric Acid, indicating substantial stereospecificity for nicotine receptors.
Studies on the disposition of phencyclidine in mice.
SYNTHESIS AND PRELIMINARY BINDING STUDIES OF 4,4-DITRITIO-(-)-NICOTINE OF HIGH SPECIFIC ACTIVITY
Nonisothermal kinetic studies III: rapid nonisothermal-isothermal method for stability prediction.
- M. Zoglio, H. V. Maulding, W. Streng, W. Vincek
- ChemistryJournal of pharmaceutical sciences
- 1 August 1975
A continuous nonisothermal-isothermal method for stability prediction was developed that yields all necessary parameters for prediction, including reaction order, which is applicable to acid-catalyzed hydrolysis of acetylcholine bromide and the inversion of sucrose.
Synthesis of 4,4-ditritio-(+)-nicotine: comparative binding and distribution studies with natural enantiomer.
- W. Vincek, B. Martin, M. Aceto, H. Tripathi, E. May, L. Harris
- Chemistry, BiologyJournal of pharmaceutical sciences
- 1 November 1981
Although Ib is 10-30 times less potent than (-)-nicotine (Ia) in the CNS, its binding affinity for the crude mitochondrial or nuclear fraction of whole rat brain is only three times less than that of Ia, and distribution studies showed that the maximum brain levels of (-)-[3H] nicotine are nearly twice those of (+)-[ 3H]-nicotine following administration of a 2-micrograms/kg dose.
Enterohepatic circulation of sulindac and metabolites
- C. Dujovne, A. Pitterman, W. Vincek, M. Dobrinska, R. Davies, D. E. Duggan
- Medicine, BiologyClinical pharmacology and therapeutics
- 1 February 1983
There is a correlation between data in man and those in five other species and the data established that, after sulindac, the contribution of enterohepatic circulation to conservation of the active pharmacophore is achieved predominantly at the level of inactive prodrug.