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Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse
Two G protein‐coupled receptors have been identified that bind corticotropin‐releasing factor (CRF) and urocortin (UCN) with high affinity. Hybridization histochemical methods were used to shed lightExpand
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Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients.
The possibility that hypersecretion of corticotropin-releasing factor (CRF) contributes to the hyperactivity of the hypothalamo-pituitary-adrenal axis observed in patients with major depression wasExpand
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Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules
Plethora of Secretory Amyloids Protein aggregation and the formation of amyloids are associated with several dozen pathological conditions in humans, including Alzheimer's disease, Parkinson'sExpand
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Appetite-Suppressing Effects of Urocortin, a CRF-Related Neuropeptide
The neuropeptide corticotropin-releasing factor (CRF) is well known to act on the central nervous system in ways that mimic stress and result in decreases in exploration, increases in sympatheticExpand
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Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart.
Corticotropin-releasing factor (CRF; corticoliberin) regulates the secretion of corticotropin (ACTH) and beta-endorphin and has a broad range of effects on the nervous, endocrine, reproductive,Expand
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Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A.
Cyclic AMP (cAMP) regulates a number of eukaryotic genes by mediating the protein kinase A (PKA)-dependent phosphorylation of the CREB transcription factor at Ser-133. In this study, we test theExpand
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Corticotropin releasing factor decreases postburst hyperpolarizations and excites hippocampal neurons.
Corticotropin releasing factor in concentrations of 15 to 250 nanomoles per liter increased the spontaneous discharge frequency and decreased the size of hyperpolarizations after burst discharges inExpand
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Development of Cushing's syndrome in corticotropin-releasing factor transgenic mice.
CRF is released in response to various stressors and regulates ACTH secretion and glucocorticoid production. CRF overproduction has been implicated in affective disorders, such as depression andExpand
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Corticotropin-Releasing Factor Receptors Differentially Regulate Stress-Induced Tau Phosphorylation
Hyperphosphorylation of the microtubule-associated protein tau is a key event in the development of Alzheimer's disease (AD) neuropathology. Acute stress can induce hippocampal tau phosphorylationExpand
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Patterns of growth hormone-releasing factor and somatostatin secretion into the hypophysial-portal circulation of the rat.
The interrelation between the secretion of two hypophysiotropic peptides, growth hormone-releasing factor (GRF) and somatostatin (SRIF), in the generation of episodic growth hormone (GH) secretionExpand
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