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Molecular Basis for Enantioselectivity of Lipase from Pseudomonas cepacia toward Primary Alcohols. Modeling, Kinetics, and Chemical Modification of Tyr29 to Increase or Decrease Enantioselectivity.
This work used a combination of molecular modeling of lipase-transition state analogue complexes and kinetic measurements to identify the molecular basis of the enantioselectivity of PCL toward two primary alcohols: 2-methyl-3-phenyl-1-propanol, 1, and 2-phenoxy- 1-pro panol, 2.
Appropriating the tools of research : patent law and biotechnology
Patent law creates economic incentives for individuals and companies to invest in research and development, as well as to disclose publicly and commercialize new inventions. In creating these