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Molecular Basis for Enantioselectivity of Lipase from Pseudomonas cepacia toward Primary Alcohols. Modeling, Kinetics, and Chemical Modification of Tyr29 to Increase or Decrease Enantioselectivity.
TLDR
This work used a combination of molecular modeling of lipase-transition state analogue complexes and kinetic measurements to identify the molecular basis of the enantioselectivity of PCL toward two primary alcohols: 2-methyl-3-phenyl-1-propanol, 1, and 2-phenoxy- 1-pro panol, 2.
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