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Reversal of P-glycoprotein-mediated multidrug resistance by XR9051, a novel diketopiperazine derivative.
Results indicate that XR9051 reverses the MDR phenotype through direct interaction with P-glycoprotein.
Changes in protein kinase C isoenzyme expression associated with apoptosis in U937 myelomonocytic cells.
The data indicate that the expression of specific PKC isoenzymes is modulated during apoptosis and thatPKC-beta and PKC-zeta may play specific roles in the regulation of the apoptotic program.
ReversalofP-glycoprotein-m ediated multidrug resistance byXR9051,a noveldiketopiperazine derivative
- W. Tuffley
- Chemistry, Biology
Results indicate that XR9051 reverses the MDR phenotype through direct interaction withP-glycoprotein, and is consistently morepotent thancyclosporin A (CsA) andverapamil (Vpm) in allassaysused.