• Publications
  • Influence
Nonclinical toxicology studies with zidovudine: genetic toxicity tests and carcinogenicity bioassays in mice and rats.
Zidovudine (ZDV), an antiviral drug active in the treatment of acquired immunodeficiency syndrome (recommended human dose, 100 mg every 4 hr while awake), was evaluated for mutagenic and carcinogenicExpand
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Infected prosthetic grafts.
An experience with 20 infected prosthetic grafts in a series of 652 prosthetic arterial reconstructions has been reviewed. There was 13 aortofemoral, one straight aortic, three femoropopliteal, oneExpand
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Postoperative necrotizing fasciitis of the abdominal wall.
Abstract Postoperative necrotizing fasciitis of the abdominal wall is usually caused by peritonitis in patients who have undergone multiple procedures for complications of emergency laparotomy.Expand
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Preclinical toxicology studies with acyclovir: teratologic, reproductive and neonatal tests.
Five studies were done to define the potential of Acyclovir (ACV), a new nucleoside analog for antiviral chemotherapy, to produce adverse effects on reproduction and development in laboratoryExpand
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Preclinical toxicology of bupropion: an overview.
  • W. Tucker
  • Medicine
  • The Journal of clinical psychiatry
  • 1983
In preclinical studies, the toxicologic profile of bupropion was determined in laboratory animals using exaggerated doses of drug in a variety of toxicologic assays. Under overdose conditions,Expand
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Injuries in sport.
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Preclinical toxicology studies with acyclovir: genetic toxicity tests.
Acyclovir (ACV), an antiviral drug active in the treatment of oral and genital Herpes infections, has been evaluated for mutagenic and carcinogenic potential in a battery of in vitro and in vivoExpand
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Treatment of experimental herpes simplex keratitis with acycloguanosine.
Acycloguanosine, a recently developed compound with high inhibitory activity against viruses belonging to the herpes group, has been evaluated in experimental herpes simplex keratitis in rabbits inExpand
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Sex- and species-related nephropathy of 6-(1-aminocyclohexanecarboxamido)penicillanic acid (cyclacillin) and its relationship to the metabolic disposition of the drug.
Abstract In COBS-CD rats treated with cyclacillin for 4 weeks there were no drug-related histologic changes, but after 26 weeks of treatment a chronic proliferative and degenerative nephropathy wasExpand
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Metabolic and pathologic investigation of 1-aminocyclohexanecarboxylic acid (ACHC), a metabolite of 6-(1-aminocyclohexanecarboxamido)-penicillanic acid (cyclacillin).
Abstract A nephrotoxic effect was noted in male but not in female COBS-CD rats chronically treated with 1-aminocyclohexanecarboxylic acid (ACHC), a metabolite ofExpand
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