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Cytochrome P450 and manganese superoxide dismutase genes polymorphisms in systemic lupus erythematosus.
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Lapatinib inhibits CIP2A/PP2A/p-Akt signaling and induces apoptosis in triple negative breast cancer cells
TLDR
Inhibition of CIP2A determines the effects of lapatinib-induced apoptosis in TNBC cells, and lapatinIB showed anti-tumor activity in mice bearing MDA-MB-468 xenograft tumors, and suppressed C IP2A as well as p-Akt in these xenografted tumors.
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The tyrosine kinase inhibitor nintedanib activates SHP-1 and induces apoptosis in triple-negative breast cancer cells
TLDR
The results demonstrated that nintedanib enhanced TNBC cell apoptosis, which was accompanied by a reduction of p-STAT3 and its downstream proteins, and validates the role of SHP-1 in nintEDanib-mediated apoptosis.
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Natural resistance-associated macrophage protein 1 gene polymorphisms in rheumatoid arthritis.
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Manganese superoxide dismutase and cytochrome P450 1A1 genes polymorphisms in rheumatoid arthritis in Taiwan.
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EGFR-independent Elk1/CIP2A signalling mediates apoptotic effect of an erlotinib derivative TD52 in triple-negative breast cancer cells.
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Sorafenib analogue SC‐60 induces apoptosis through the SHP‐1/STAT3 pathway and enhances docetaxel cytotoxicity in triple‐negative breast cancer cells
TLDR
A sorafenib analogue SC‐60, which lacks angiokinase inhibition activity, but acts as a SHP‐1 agonist, displayed a significant antitumor effect in an MDA‐MB‐468 xenograft model by modulating the SHp‐1/STAT3 axis, indicating the anticancer potential ofSC‐60 in TNBC treatment.
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Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in ankylosing spondylitis.
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Cytochrome P450 1A1 and manganese superoxide dismutase gene polymorphisms in Behçet's disease.
TLDR
Simultaneous presence of CYP1A1 4889G and 4887A is associated with development of BD in Taiwan.
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Sequential combination of docetaxel with a SHP-1 agonist enhanced suppression of p-STAT3 signaling and apoptosis in triple negative breast cancer cells
TLDR
The results suggest that the novel SHP-1 agonist SC-43 enhanced docetaxel-induced cytotoxicity by SHp-1 dependent STAT3 inhibition in human triple negative breast cancer cells.
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