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Cytochrome P450 and manganese superoxide dismutase genes polymorphisms in systemic lupus erythematosus.
Lapatinib inhibits CIP2A/PP2A/p-Akt signaling and induces apoptosis in triple negative breast cancer cells
Inhibition of CIP2A determines the effects of lapatinib-induced apoptosis in TNBC cells, and lapatinIB showed anti-tumor activity in mice bearing MDA-MB-468 xenograft tumors, and suppressed C IP2A as well as p-Akt in these xenografted tumors.
The tyrosine kinase inhibitor nintedanib activates SHP-1 and induces apoptosis in triple-negative breast cancer cells
- Chun-Yu Liu, Tzu-Ting Huang, Kuen-Feng Chen
- Biology, ChemistryExperimental &Molecular Medicine
- 1 August 2017
The results demonstrated that nintedanib enhanced TNBC cell apoptosis, which was accompanied by a reduction of p-STAT3 and its downstream proteins, and validates the role of SHP-1 in nintEDanib-mediated apoptosis.
Natural resistance-associated macrophage protein 1 gene polymorphisms in rheumatoid arthritis.
Manganese superoxide dismutase and cytochrome P450 1A1 genes polymorphisms in rheumatoid arthritis in Taiwan.
EGFR-independent Elk1/CIP2A signalling mediates apoptotic effect of an erlotinib derivative TD52 in triple-negative breast cancer cells.
Sorafenib analogue SC‐60 induces apoptosis through the SHP‐1/STAT3 pathway and enhances docetaxel cytotoxicity in triple‐negative breast cancer cells
A sorafenib analogue SC‐60, which lacks angiokinase inhibition activity, but acts as a SHP‐1 agonist, displayed a significant antitumor effect in an MDA‐MB‐468 xenograft model by modulating the SHp‐1/STAT3 axis, indicating the anticancer potential ofSC‐60 in TNBC treatment.
Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in ankylosing spondylitis.
Cytochrome P450 1A1 and manganese superoxide dismutase gene polymorphisms in Behçet's disease.
- J. Yen, W. Tsai, Chia-Hui Lin, T. Ou, Chaur-Jong Hu, Hong-wen Liu
- Biology, MedicineThe Journal of rheumatology
- 1 April 2004
Simultaneous presence of CYP1A1 4889G and 4887A is associated with development of BD in Taiwan.
Sequential combination of docetaxel with a SHP-1 agonist enhanced suppression of p-STAT3 signaling and apoptosis in triple negative breast cancer cells
The results suggest that the novel SHP-1 agonist SC-43 enhanced docetaxel-induced cytotoxicity by SHp-1 dependent STAT3 inhibition in human triple negative breast cancer cells.