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Acetylcholine activation of single muscarinic K+ channels in isolated pacemaker cells of the mammalian heart
TLDR
The results show that the ACh-dependent K+ conductance increase in nodal cells is mediated by K+ channels which are different in their gating and conductance properties from the inward rectifying resting K- channels in atrial and ventricular cells. Expand
The GTP-binding protein, Go9 regulates neuronal calcium channels
TLDR
An inhibitory effect of the opioid D-Ala2, D-Leu5-enkephalin (DADLE) on the calcium current (ICa) in neuroblastoma x glioma hybrid cells (N x G cells) is reported and it is proposed that Go is involved in the functional coupling of opiate receptors to neuronal voltage-dependent calcium channels. Expand
Potentiation by cyclic GMP of beta‐adrenergic effect on Ca2+ current in guinea‐pig ventricular cells.
TLDR
Investigation in myocytes isolated from guinea‐pig ventricles suggested the presence of antagonistic mechanisms of cyclic GMP, which are independent from the above synergistic action, and PKG may be involved in this antagonistic effect. Expand
Relaxation of the ACh-induced potassium current in the rabbit sinoatrial node cell
TLDR
The results suggest that ACh opens a specific potassium channel when the drug is bound to the muscarinic receptor. Expand
Calcium currents in single SA nodal cells of the rabbit heart studied with action potential clamp
With a new method called “Action Potential-Clamp” (APC) we studied in single SA nodal cells the contribution of both transient and long lasting calcium currents (L-type and T-type) to the actionExpand
Regulation of cardiac L-type calcium current by phosphorylation and G proteins.
TLDR
Voltage-dependent Ca2+ channels play a major role in the electromechanical coupling of cardiac cells and are involved in the spontaneous impulse generation as well as in the duration of the action potentials and hence in refractoriness. Expand
On the mechanism of β-adrenergic regulation of the Ca channel in the guinea-pig heart
Dose-response relations for the increase in the amplitude of Ca current (ICa) on external application of isoprenaline (ISP) and internally applied cyclic AMP (cAMP) or catalytic subunit ofExpand
Diversity and novel pharmacological properties of Ca2+ channels in Drosophila brain membranes.
TLDR
The Drosophila system seems to be a unique model to analyse the properties of several different types of Ca2+ channels and particularly those of channel types that are uniquely blocked by phenylalkylamines or uniquely blockedby 1,4‐dihydropyridines. Expand
VAGAL AND SYMPATHETIC EFFECTS ON THE PACEMAKER FIBERS IN THE SINUS VENOSUS OF THE HEART
TLDR
It is proposed that the fibers showing the largest fall in membrane potential during diastole are the pacemaker fibers of the heart, and that the rest of the preparation is excited by conduction. Expand
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