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New diagnostic criteria for multiple sclerosis: Guidelines for research protocols
TLDR
Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS. Expand
Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis.
TLDR
Understanding the cellular interactions between premyelinating oligodendrocytes, axons, and the microenvironment of lesions of multiple sclerosis may lead to effective strategies for enhancing remyelination. Expand
Recommended standard of cerebrospinal fluid analysis in the diagnosis of multiple sclerosis: a consensus statement.
TLDR
Recommendations for establishing a standard for the evaluation of CSF in patients suspected of having MS should greatly complement the new criteria in ensuring that a correct diagnosis of MS is being made. Expand
Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease.
TLDR
It is suggested that M-CSF, thus generated, contributes to the pathogenesis of AD, and that M -CSF in cerebrospinal fluid might provide a means for monitoring neuronal perturbation at an early stage in AD. Expand
Human brain dopamine receptors in children and aging adults
TLDR
The observed decline in the human D1/D2 ratio with age suggests that the perioral control mechanisms for humans and rats may be different. Expand
Painful symptoms reported by ambulatory HIV-infected men in a longitudinal study
TLDR
It is concluded that painful symptoms are important even in relatively healthy and independent HIV‐infected men. Expand
Immunohistochemical and genetic evidence of myeloperoxidase involvement in multiple sclerosis
TLDR
The present study shows that the higher expressing MPO genotype is overrepresented in early onset multiple sclerosis in females, implicating MPO in this demyelinating disease. Expand
Marked increase in cyclooxygenase-2 in ALS spinal cord
TLDR
The strong upregulation of COX-2 mRNA in ALS is in accord with studies in the superoxide dismutase transgenic mouse model in which COx-2 upregulation occurs, and is supportive of a possible future role for COZ-2 inhibitors in the treatment of ALS. Expand
Early penetration of the blood‐brain‐barrier by HIV
TLDR
It is indicated that HIV infects the CNS early in the course of viral infection and prior to the development of HIV-associated neurologic abnormalities. Expand
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