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Sequence to structure approach of estrogen receptor alpha and ligand interactions.
Estrogen receptors (ERs) are steroid receptors located in the cytoplasm and on the nuclear membrane. The sequence similarities of human ERα, mouse ERα, rat ERα, dog ERα, and cat ERα are above 90%,Expand
Immunohistochemical determination of estrogen and progesterone receptors in canine mammary tumors.
Mammary gland tumors are by far the most commonly found tumors in domestic dogs. Effective therapeutic procedures with prompt accurate diagnoses are of prime importance for this life threateningExpand
Comparative Studies of Actin- and Rho-Specific ADP-Ribosylating Toxins: Insight from Structural Biology.
Mono-ADP-ribosylation is a major post-translational modification performed by bacterial toxins, which transfer an ADP-ribose moiety to a substrate acceptor residue. Actin- and Rho-specificExpand
Crystal structure and structure-based mutagenesis of actin-specific ADP-ribosylating toxin CPILE-a as novel enterotoxin
Unusual outbreaks of food poisoning in Japan were reported in which Clostridium perfringens was strongly suspected to be the cause based on epidemiological information and fingerprinting of isolates.Expand
Binding capacity of ER-α ligands and SERMs: comparison of the human, dog and cat.
The estrogen molecule is the major risk factor related to mammary gland tumors, with estrogen receptor alpha (ER- α) as the important target stimulating growth. Therefore one alternative approach toExpand
Effect of single mutagenesis on the binding pocket of canine estrogen receptor alpha: Structure and binding affinity
Hormone-related mammary gland tumors are among the most commonly diagnosed neoplasms in female dogs. Estrogen enacts its biological roles through specific receptors known as estrogen receptors (ER).Expand
Preliminary report: homology modeling of human, dog and catβ-adrenergic receptors
Beta 2-adrenergic Receptors are widely distributed in heart, airway smooth muscle, liver, skeletal muscle and adipose tissue. The specific ligand, beta 2-agonist, binds at the specific binding siteExpand
Adult stem cells and stem cell niche play important roles in primary mammary tumors.
Cancer biology and molecular biology of mammary tumors have been studied so far. New cell biology concept about stem cells and stem cell niches provides the important knowledge that mammary stemExpand
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