Superoxide Production and Expression of Nox Family Proteins in Human Atherosclerosis
- D. Sorescu, D. Weiss, K. Griendling
- Medicine, BiologyCirculation
- 26 March 2002
Several Nox proteins, including gp91phox and Nox4, may contribute to increased intracellular oxidative stress in human coronary atherosclerosis in a cell-specific manner and thus may be involved in the genesis and progression of human coronary Atherosclerotic disease.
Role of NADH/NADPH oxidase-derived H2O2 in angiotensin II-induced vascular hypertrophy.
- A. Zafari, M. Ushio-Fukai, K. Griendling
- Biology, ChemistryHYPERTENSION
- 1 September 1998
Data indicate that AT1 receptor-mediated production of superoxide generated by the NADH/NADPH oxidase is followed by an increase in intracellular H2O2, suggesting a specific role for these oxygen species and scavenging systems in modifying the intrACEllular redox state in vascular growth.
Bone Morphogenic Protein 4 Produced in Endothelial Cells by Oscillatory Shear Stress Stimulates an Inflammatory Response*
- G. Sorescu, M. Sykes, H. Jo
- BiologyJournal of Biological Chemistry
- 15 August 2003
It is suggested that BMP4 is a mechanosensitive, inflammatory factor playing a critical role in early steps of atherogenesis in the lesion-prone areas.
Bioartificial matrices for therapeutic vascularization
- E. A. Phelps, N. Landázuri, P. Thulé, W. Taylor, Andrés J. García
- Biology, EngineeringProceedings of the National Academy of Sciences
- 31 December 2009
The application of engineered bioartificial matrices to promote vascularization for directed regenerative therapies is supported and the mechanism of enhanced vascularization is likely cell-demanded release of VEGF, as the hydrogels may degrade substantially within 2 weeks.
Quantitative microcomputed tomography analysis of collateral vessel development after ischemic injury.
- C. Duvall, W. Taylor, D. Weiss, R. Guldberg
- BiologyAmerican Journal of Physiology. Heart and…
- 1 July 2004
The utility of microcomputed tomography as a robust method for quantitative, three-dimensional analysis of blood vessel networks is demonstrated and the developed techniques may be applied to a variety of model systems to investigate mechanisms of angiogenesis and arteriogenesis.
Nox1 Overexpression Potentiates Angiotensin II-Induced Hypertension and Vascular Smooth Muscle Hypertrophy in Transgenic Mice
- A. Dikalova, R. Clempus, K. Griendling
- Biology, MedicineCirculation
- 25 October 2005
Data indicate that smooth muscle-specific Nox1 overexpression augments the oxidative, pressor, and hypertrophic responses to Ang II, supporting the concept that medial Nox 1 participates in the development of cardiovascular pathologies.
Increased circulating endothelial progenitor cells are associated with survival in acute lung injury.
- E. Burnham, W. Taylor, A. Quyyumi, M. Rojas, K. Brigham, M. Moss
- Medicine, BiologyAmerican Journal of Respiratory and Critical Care…
- 1 October 2005
It is hypothesized that increased numbers of circulating endothelial progenitor cells will be associated with an improved outcome in acute lung injury and the acute respiratory distress syndrome and improved survival is associated with improved survival.
The role of the adventitia in vascular inflammation.
- K. Maiellaro, W. Taylor
- BiologyCardiovascular Research
- 1 September 2007
Hemodynamic Shear Stresses in Mouse Aortas: Implications for Atherogenesis
- J. Suo, D. Ferrara, D. Sorescu, R. Guldberg, W. Taylor, D. Giddens
- Biology, MedicineArteriosclerosis, Thrombosis and Vascular Biology
- 22 November 2006
The results suggest that relative differences in WSS or in the direction of WSS, as opposed to the absolute magnitude, may be relevant determinants of flow-mediated inflammatory responses.
Cellular Mechanisms of Aortic Aneurysm Formation.
- Raymundo A. Quintana, W. Taylor
- Medicine, BiologyCirculation Research
- 15 February 2019
A review of the various proposed cellular mechanisms responsible for aortic aneurysm formation is examined and opportunities for future studies are identified.
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