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The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control.
Nuclear export of mRNA is tightly linked to transcription, nuclear mRNA processing, and subsequent maturation in the cytoplasm. Tip-associated protein (TAP) is the major nuclear mRNA export receptor,Expand
A Novel Spliceosome Containing U11, U12, and U5 snRNPs Excises a Minor Class (AT–AC) Intron In Vitro
A minor class of introns with noncanonical splice (AT-AC) and branch site sequences exists in metazoan protein coding genes. We have established a HeLa cell in vitro system that accurately splices aExpand
Highly Diverged U4 and U6 Small Nuclear RNAs Required for Splicing Rare AT-AC Introns
Removal of a rare class of metazoan precursor messenger RNA introns with AU-AC at their termini is catalyzed by a spliceosome that contains U11, U12, and U5 small nuclear ribonucleoproteins. TwoExpand
Transportin-SR2 mediates nuclear import of phosphorylated SR proteins
  • M. Lai, R. Lin, W. Tarn
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 21 August 2001
Serine/arginine-rich proteins (SR proteins) are a family of nuclear factors that play important roles in both constitutive and regulated precursor mRNA splicing. The domain rich in arginine/serineExpand
TRAP150 activates pre-mRNA splicing and promotes nuclear mRNA degradation
TRAP150 has been identified as a subunit of the transcription regulatory complex TRAP/Mediator, and also a component of the spliceosome. The exact function of TRAP150, however, remains unclear. WeExpand
A Human Importin-β Family Protein, Transportin-SR2, Interacts with the Phosphorylated RS Domain of SR Proteins*
Serine/arginine-rich proteins (SR proteins) are mainly involved in the splicing of precursor mRNA. RS domains are also found in proteins that have influence on other aspects of gene expression.Expand
The Pioneer Round of Translation: Features and Functions
In mammalian cells, newly synthesized mRNAs undergo a pioneer round of translation that is important for mRNA quality control. Following maturation of messenger ribonucleoprotein particles during andExpand
DDX3 Regulates Cell Growth through Translational Control of Cyclin E1
ABSTRACT DDX3 belongs to the DEAD box family of RNA helicases, but the details of its biological function remain largely unclear. Here we show that knockdown of DDX3 expression impedes G1/S-phaseExpand
A novel splicing regulator shares a nuclear import pathway with SR proteins
Alternative splicing of precursor mRNA is often regulated by serine/arginine‐rich proteins (SR proteins) and hnRNPs, and varying their concentration in the nucleus can be a mechanism for controllingExpand
Phosphorylation of the arginine/serine dipeptide‐rich motif of the severe acute respiratory syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity
Coronavirus nucleocapsid protein is abundant in infected cells and participates in viral RNA replication and transcription. The central domain of the nucleocapsid protein contains severalExpand