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A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus
- L. Prokunina-Olsson, B. Muchmore, +21 authors T. O'Brien
- Biology, Medicine
- Nature Genetics
- 1 February 2013
Chronic infection with hepatitis C virus (HCV) is a common cause of liver cirrhosis and cancer. We performed RNA sequencing in primary human hepatocytes activated with synthetic double-stranded RNA… Expand
Hydroxychloroquine in patients with COVID-19: an open-label, randomized, controlled trial
Abstract Objectives To assess the efficacy and safety of hydroxychloroquine (HCQ) plus standard-of-care (SOC) compared with SOC alone in adult patients with COVID-19. Design Multicenter, open-label,… Expand
Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro.
Chlorogenic acid and its related compounds are abundant plant polyphenols that have a diverse antiviral activity. In this study, HepG2.2.15 cells and duck hepatitis B virus infection model were used… Expand
Serum PCSK9 is associated with multiple metabolic factors in a large Han Chinese population.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease that regulates cholesterol metabolism through low-density lipoprotein receptor (LDLR) degradation. Gain-of-function and… Expand
Heavy Metal Contamination in the Surface Sediments of Representative Limnetic Ecosystems in Eastern China
- W. Tang, B. Shan, +5 authors X. Zhu
- Environmental Science, Medicine
- Scientific reports
- 21 November 2014
A comprehensive analysis of heavy metal pollution was conducted in the representative limnetic ecosystems of eastern China, which are subject to rapid economic development and population growth. The… Expand
Comparison of cadmium and lead sorption by Phyllostachys pubescens biochar produced under a low-oxygen pyrolysis atmosphere.
Phyllostachys pubescens (PP) biochars produced under a low oxygen pyrolysis atmosphere (oxygen content 1-4%) were prepared as sorbents for investigating the mechanisms of cadmium and lead sorption. A… Expand
Heavy metal sources and associated risk in response to agricultural intensification in the estuarine sediments of Chaohu Lake Valley, East China.
- W. Tang, B. Shan, H. Zhang, Zhan-po Mao
- Medicine, Environmental Science
- Journal of hazardous materials
- 15 April 2010
In this study, the source and risk associated with heavy metals in the estuarine sediments of Chaohu Lake Valley in East China were studied. The results demonstrated that most metal contents (Cd, Pb… Expand
Co-analysis of RAS Log and Job Log on Blue Gene/P
- Ziming Zheng, Li Yu, +5 authors D. Buettner
- Computer Science
- IEEE International Parallel & Distributed…
- 16 May 2011
We analyze the Blue Gene/P RAS logs and the BlueGene/P job logs in a cooperative manner. Expand
Purification of a new manganese peroxidase of the white-rot fungus Schizophyllum sp. F17, and decolorization of azo dyes by the enzyme
Abstract The manganese peroxidase (MnP) was isolated and purified from Schizophyllum sp. F17 on pinewood solid-state cultures. Fractionation of MnP was performed by Sephadex G-75 gel filtration… Expand
Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor.
- Glenn S. Van Aller, J. D. Carson, +5 authors Lusong Luo
- Biology, Medicine
- Biochemical and biophysical research…
- 11 March 2011
The PI3K signaling pathway is activated in a broad spectrum of human cancers, either directly by genetic mutation or indirectly via activation of receptor tyrosine kinases or inactivation of the PTEN… Expand