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A Novel Coronavirus from Patients with Pneumonia in China, 2019
Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding
Detection of SARS-CoV-2 in Different Types of Clinical Specimens.
This study describes results of PCR and viral RNA testing for SARS-CoV-2 in bronchoalveolar fluid, sputum, feces, blood, and urine specimens from patients with COVID-19 infection in China to identify…
Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China
In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
- Xueting Yao, F. Ye, Dongyang Liu
- Medicine, BiologyClinical infectious diseases : an official…
- 9 March 2020
It is proposed that the immunomodulatory effect of hydroxychloroquine also may be useful in controlling the cytokine storm that occurs late-phase in critically ill SARS-CoV-2 infected patients.
Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2
It is found that SARS-CoV-2 replicates poorly in dogs, pigs, chickens, and ducks, but ferrets and cats are permissive to infection and Additionally, cats are susceptible to airborne transmission.
A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2
In isolation of four human-origin monoclonal antibodies from a convalescent patient, all of which display neutralization abilities, a therapeutic study in a mouse model validated that these antibodies can reduce virus titers in infected lungs.
High-Throughput Screening and Identification of Potent Broad-Spectrum Inhibitors of Coronaviruses
Seven compounds were identified as broad-spectrum inhibitors according to their strong inhibition of replication by four CoVs in vitro at low-micromolar concentrations and emetine blocked MERS-CoV entry according to pseudovirus entry assays and lycorine protected BALB/c mice against HCoV-OC43-induced lethality by decreasing viral load in the central nervous system.
Development of an Inactivated Vaccine Candidate, BBIBP-CorV, with Potent Protection against SARS-CoV-2
The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of Middle East respiratory syndrome coronavirus (MERS-CoV) are potent interferon antagonists
It is revealed that the ORF 4a protein of MERS-CoV has the most potential to counteract the antiviral effects of IFN via the inhibition of both the interferon production and ISRE promoter element signaling pathways.